PMID- 15735532
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20161021
IS  - 0351-3254 (Print)
IS  - 0351-3254 (Linking)
VI  - 25
IP  - 1-2
DP  - 2004
TI  - [The role of the von Willebrand factor in renal diseases and haemodialysis 
      patients].
PG  - 5-15
AB  - During a period of twenty years, the von Willebrand factor (VWf) biological 
      activity was evaluated in 805 patients with vein thrombosis, diabetes mellitus, 
      chronic renal failure and ischemic heart disease. The examined patients were 168 
      with vein thrombosis, 129 with diabetes mellitus, 412 with chronic renal failure 
      (CRF), and 96 with ischemic heart disease. The biological activity was also 
      determined in 104 haemodialysis patients using four different haemodialytic 
      membranes: 30 on cuprophan membrane, 30 on polymethylmetacrylate membrane (PMMA), 
      24 on hemophane and 20 patients on polysulphone (PS) membrane. In 42 patients 
      with arterio-venous fistula prone to thrombosis, the biological activity of the 
      von Willebrand Factor was 178% in comparison to 106% in the control group. The 
      biological activity of VWF was increased in patients with vein thrombosis (p < 
      0.02), in patients with diabetes mellitus (p < 0.01), CRF (p < 0.05), and in 
      patients with ischemic heart disease (p < 0.01). The highest biological activity 
      was found in patients on PMMA (p < 0.001), then cuprophan (p < 0.05) and 
      hemophane membrane (p < 0.01), while the lowest increase of its concentration was 
      noticed in patients on PS without statistical significance. In arteriovenous 
      fistula prone to thrombosis patients biological activity of the von Willebrand 
      Factor was significantly increased (p < 0.01). Our investigations show the 
      importance of VWF as a marker of endothelial disfunction, a possible predictor of 
      A-V fistula thrombosis, and a possible marker of haemodialysis membranes 
      biocompatibility.
FAU - Dejanov, P
AU  - Dejanov P
FAU - Polenakovic, M
AU  - Polenakovic M
FAU - Oncevski, A
AU  - Oncevski A
FAU - Sikole, A
AU  - Sikole A
FAU - Dejanova, B
AU  - Dejanova B
FAU - Panov, S
AU  - Panov S
FAU - Kostovska, S
AU  - Kostovska S
LA  - mac
PT  - English Abstract
PT  - Journal Article
TT  - Bioloskata aktivnost na fon Vilebranodoviot faktor kaj bubrezni i hemodijalizni 
      bolni.
PL  - Germany
TA  - Prilozi
JT  - Prilozi
JID - 101189513
RN  - 0 (von Willebrand Factor)
SB  - IM
MH  - Diabetes Mellitus/blood
MH  - Humans
MH  - Kidney Failure, Chronic/*blood
MH  - Myocardial Ischemia/blood
MH  - *Renal Dialysis
MH  - Venous Thrombosis/blood
MH  - von Willebrand Factor/*analysis
EDAT- 2005/03/01 09:00
MHDA- 2006/03/22 09:00
CRDT- 2005/03/01 09:00
PHST- 2005/03/01 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2005/03/01 09:00 [entrez]
PST - ppublish
SO  - Prilozi. 2004;25(1-2):5-15.