PMID- 15735992
OWN - NLM
STAT- MEDLINE
DCOM- 20050623
LR  - 20150216
IS  - 0028-3843 (Print)
IS  - 0028-3843 (Linking)
VI  - 39
IP  - 1
DP  - 2005 Jan-Feb
TI  - [Role of matrix metalloproteinases in the pathogenesis of multiple sclerosis].
PG  - 63-7
AB  - Multiple sclerosis (MS) is an autoimmune disease whose features include a massive 
      lymphocyte recruitment into the central nervous system and segmental 
      demyelinization of the white matter. One of the MS development factors is an 
      increase of matrix metalloproteinases (MMPs) activity with a coincidental 
      decrease of tissue inhibitors of MMPs (TIMPs) activity. Investigations of serum, 
      cerebrospinal fluid and brain tissue of patients showed an increase of MMP-1, -2, 
      -3, -7, -9 and MMP-12 activity. MMPs disrupt the blood-brain barrier (BBB), 
      increase lymphocyte migration into the central nervous system and are involved in 
      degradation of myelin proteins. MMPs induce the appearance of an active form of 
      tumor necrosis factor alpha, a strong proinflammatory cytokine. The drugs used in 
      MS treatment decrease MMPs expression. Multiple actions of MMPs prove their 
      involvement in the pathogenesis and treatment of MS.
FAU - Kurzepa, Jacek
AU  - Kurzepa J
AD  - Katedra i Zaklad Biochemii, Katedra i Klinika Neurologii, Akademia Medyczna im. 
      prof. Feliksa Skubiszewskiego w Lublinie, ul. Jaczewskiego 8, 20-954 Lublin, 
      Poland.
FAU - Bartosik-Psujek, Halina
AU  - Bartosik-Psujek H
FAU - Suchozebrska-Jesionek, Danuta
AU  - Suchozebrska-Jesionek D
FAU - Rejdak, Konrad
AU  - Rejdak K
FAU - Stryjecka-Zimmer, Marta
AU  - Stryjecka-Zimmer M
FAU - Stelmasiak, Zbigniew
AU  - Stelmasiak Z
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Rola metaloproteinaz macierzy zewnatrzkomorkowej w patogenezie stwardnienia 
      rozsianego.
PL  - Poland
TA  - Neurol Neurochir Pol
JT  - Neurologia i neurochirurgia polska
JID - 0101265
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Blood-Brain Barrier/enzymology/*metabolism
MH  - Central Nervous System/enzymology
MH  - Humans
MH  - Matrix Metalloproteinases/*metabolism
MH  - Multiple Sclerosis/*enzymology/immunology
MH  - Tissue Inhibitor of Metalloproteinases/*metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
RF  - 26
EDAT- 2005/03/01 09:00
MHDA- 2005/06/24 09:00
CRDT- 2005/03/01 09:00
PHST- 2005/03/01 09:00 [pubmed]
PHST- 2005/06/24 09:00 [medline]
PHST- 2005/03/01 09:00 [entrez]
AID - 2941 [pii]
PST - ppublish
SO  - Neurol Neurochir Pol. 2005 Jan-Feb;39(1):63-7.