PMID- 15736225
OWN - NLM
STAT- MEDLINE
DCOM- 20050907
LR  - 20071115
IS  - 1058-8388 (Print)
IS  - 1058-8388 (Linking)
VI  - 232
IP  - 4
DP  - 2005 Apr
TI  - Retinoid signaling competence and RARbeta-mediated gene regulation in the 
      developing mammalian telencephalon.
PG  - 887-900
AB  - To study retinoid signaling in the developing telencephalon, we transfected a 
      retinoid reporter gene into different regions of developing telencephalon. We 
      found that the ventral telencephalon was more competent to retinoid signaling 
      than the dorsal telencephalon. Moreover, among all retinoic acid receptors (RARs) 
      and retinoid X receptors (RXRs), RARbeta was strongly induced by retinoic acid in 
      the ventral telencephalon, suggesting that RARbeta might be involved in retinoid 
      signaling competence. The RT-PCR analysis indicated that RARbeta was selectively 
      expressed in the developing striatum of ventral telencephalon. We then 
      demonstrated that null mutations of RARbeta gene resulted in reduction of 
      striatal-enriched tyrosine phosphatase (STEP) mRNA in the striatum of RARbeta-/- 
      mutant mice. Conversely, the gain-of-function study showed that ectopic 
      expression of RARbeta1 in the cerebral cortex enhanced STEP expression, and the 
      effect was RARbeta-isoform specific. Our study identified RARbeta as an important 
      molecule for transducing retinoid signals in developing ventral telencephalon.
CI  - Copyright 2005 Wiley-Liss, Inc.
FAU - Liao, Wen-Lin
AU  - Liao WL
AD  - Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan 11221, 
      Taiwan, Republic of China.
FAU - Wang, Hsiao-Fang
AU  - Wang HF
FAU - Tsai, Hsiu-Chao
AU  - Tsai HC
FAU - Chambon, Pierre
AU  - Chambon P
FAU - Wagner, Michael
AU  - Wagner M
FAU - Kakizuka, Akira
AU  - Kakizuka A
FAU - Liu, Fu-Chin
AU  - Liu FC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Dyn
JT  - Developmental dynamics : an official publication of the American Association of 
      Anatomists
JID - 9201927
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (retinoic acid receptor beta)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
SB  - IM
MH  - Animals
MH  - Basal Ganglia/cytology/*embryology
MH  - Biological Transport, Active/genetics/physiology
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Protein Tyrosine Phosphatases/*biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Retinoic Acid/genetics/*metabolism
MH  - Signal Transduction/genetics/*physiology
EDAT- 2005/03/01 09:00
MHDA- 2005/09/08 09:00
CRDT- 2005/03/01 09:00
PHST- 2005/03/01 09:00 [pubmed]
PHST- 2005/09/08 09:00 [medline]
PHST- 2005/03/01 09:00 [entrez]
AID - 10.1002/dvdy.20281 [doi]
PST - ppublish
SO  - Dev Dyn. 2005 Apr;232(4):887-900. doi: 10.1002/dvdy.20281.