PMID- 15738592
OWN - NLM
STAT- MEDLINE
DCOM- 20050408
LR  - 20141225
VI  - 8
IP  - 2 Pt 1
DP  - 2004 Apr-Jun
TI  - [Solid tumours of the vertebral column and spinal cord in children. Reasons and 
      consequences of diagnostic delay].
PG  - 183-91
AB  - INTRODUCTION: Primary or secondary tumours of spinal cord and vertebral column 
      have various histological structure, various degree of malignancy and various 
      growth dynamics. Such localisation of neoplastic disease creates problems, 
      connected with the risk of irreversible damage of neurological functions. It is 
      essential to make a proper diagnosis very early. AIM: An analysis of initial 
      clinical symptoms and reasons for diagnostic delay in children with neoplasms of 
      the vertebral column and spinal cord. This can facilitate and accelerate 
      diagnostic and therapeutic process. MATERIAL AND METHODS: 20 children treated 
      from 1994 to 2004 in Department of Paediatrics, Haematology, Oncology and 
      Endocrinology in the Medical University of Gdansk, were investigated. Patients 
      were divided into 2 groups. In group I, there were 11 children with neuroblastoma 
      and peripheral primitive neuroectodermal tumour (PNET). The primary focus of the 
      neoplasm was localised beyond the vertebral column with secondary infiltration of 
      the spinal cord. Nine children were included in-group II, with primary focus in 
      the spinal cord: glioma (2), ependymoma (1), meningioma (1) and localised in 
      bones of the vertebra: osteosarcoma (2), chondrosarcoma (1), Ewing sarcoma (1) 
      and those eosinophilic granuloma (1). Patients were admitted to hospital late. In 
      group I, advanced stage of disease (III and IV) was found in 5, and stage IV in 6 
      children. In the early stage of the disease in-group II, pain and neurological 
      symptoms were predominant. Duration of symptoms was longer than in-group I. It 
      was from 6 weeks to 12 months. In both groups diagnostic delay was noted in 13 
      out of 20 patients. RESULTS: In spite of using obligatory treatment protocols 
      diagnostic delay contributed to permanent neurological complications in 65% of 
      patients.
FAU - Drozynska, Elzbieta
AU  - Drozynska E
AD  - Klinika Pediatrii, Hematologii, Onkologii i Endokrynologii, Akademia Medyczna, 
      Debinki 7, 80-211 Gdansk, Poland. edrozd@wp.pl
FAU - Polczynska, Katarzyna
AU  - Polczynska K
FAU - Bien, Ewa
AU  - Bien E
FAU - Stachowicz-Stencel, Teresa
AU  - Stachowicz-Stencel T
FAU - Stefanowicz, Joanna
AU  - Stefanowicz J
FAU - Sierota, Danuta
AU  - Sierota D
FAU - Szolkiewicz, Anna
AU  - Szolkiewicz A
FAU - Dubaniewicz, Miroslawa
AU  - Dubaniewicz M
FAU - Izycka-Swieszewska, Ewa
AU  - Izycka-Swieszewska E
FAU - Balcerska, Anna
AU  - Balcerska A
LA  - pol
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Guzy lite kregoslupa i kanalu kregowego u dzieci. Przyczyny i konsekwencje 
      opoznien rozpoznania.
PL  - Poland
TA  - Med Wieku Rozwoj
JT  - Medycyna wieku rozwojowego
JID - 100928610
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Chondrosarcoma/complications/diagnosis
MH  - Diagnosis, Differential
MH  - Eosinophilic Granuloma/complications/diagnosis
MH  - Ependymoma/complications/diagnosis
MH  - Female
MH  - Glioma/complications/diagnosis
MH  - Humans
MH  - Infant
MH  - Male
MH  - Meningioma/complications/diagnosis
MH  - Neoplasm Staging
MH  - Neuroblastoma/complications/diagnosis
MH  - Neuroectodermal Tumors, Primitive, Peripheral/complications/diagnosis
MH  - Osteosarcoma/complications/diagnosis
MH  - Poland
MH  - Retrospective Studies
MH  - Sarcoma, Ewing/complications/diagnosis
MH  - Spinal Cord Neoplasms/*complications/*diagnosis/physiopathology/therapy
MH  - Spinal Neoplasms/*complications/*diagnosis/physiopathology/therapy
MH  - Time Factors
EDAT- 2005/03/02 09:00
MHDA- 2005/04/09 09:00
CRDT- 2005/03/02 09:00
PHST- 2005/03/02 09:00 [pubmed]
PHST- 2005/04/09 09:00 [medline]
PHST- 2005/03/02 09:00 [entrez]
PST - ppublish
SO  - Med Wieku Rozwoj. 2004 Apr-Jun;8(2 Pt 1):183-91.