PMID- 15738623
OWN - NLM
STAT- MEDLINE
DCOM- 20050712
LR  - 20190724
IS  - 0031-6903 (Print)
IS  - 0031-6903 (Linking)
VI  - 125
IP  - 3
DP  - 2005 Mar
TI  - [Chemical study of citrus plants in the search for cancer chemopreventive 
      agents].
PG  - 231-54
AB  - The constituents of Citrus plants were investigated to develop useful agents that 
      are effective in cancer chemoprevention. We examined the roots and bark of the 
      roots of various Citrus plants, resulting in the isolation of many novel 
      compounds. Their structures were determined using spectroscopic methods, 
      especially 2D-NMR spectra. The following new compounds of constituents were 
      found: dimeric coumarins, dimeric acridone alkaloids, and acridone-coumarin 
      dimers. Auraptene and nobiletin are known as useful constituents of the peel of 
      Citrus plants for cancer chemoprevention. However, we found that 
      3,5,6,7,8,3',4'-heptamethoxyflavone (HPT) has both antitumor promotion and 
      initiation activities and is more effective than auraptene and nobiletin. We 
      synthesized pentaallyl quercetin (QPA), a useful antitumor compound that has the 
      additional effects of a P-glycoprotein (P-gp) inhibitor. The inhibitory effects 
      of QPA on P-gp were more effective than those of the typical P-gp inhibitors 
      cyclosporin A and verapamil. Both HPT and QPA have antitumor promotion activity 
      and are potential candidates for effective multidrug resistance agents in cancer 
      chemotherapy.
FAU - Ju-Ichi, Motoharu
AU  - Ju-Ichi M
AD  - School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya 
      663-8179, Japan. mjuichi@mwu.mukogawa-u.ac.jp
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - 0 (Acridines)
RN  - 0 (Acridones)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Coumarins)
RN  - 0 (Flavonoids)
RN  - 1178-24-1 (3,3',4',5,6,7,8-heptamethoxyflavone)
RN  - 6BK306GUQA (acridone)
RN  - 9IKM0I5T1E (Quercetin)
RN  - F79I1ZEL2E (aurapten)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors
MH  - Acridines/*isolation & purification/pharmacology
MH  - Acridones
MH  - Animals
MH  - Antineoplastic Agents/*isolation & purification/pharmacology
MH  - Citrus/*chemistry
MH  - Coumarins/*isolation & purification/pharmacology
MH  - Flavonoids/*isolation & purification/pharmacology
MH  - Humans
MH  - Nuclear Magnetic Resonance, Biomolecular/methods
MH  - Quercetin/chemical synthesis/pharmacology
MH  - Structure-Activity Relationship
RF  - 62
EDAT- 2005/03/02 09:00
MHDA- 2005/07/13 09:00
CRDT- 2005/03/02 09:00
PHST- 2005/03/02 09:00 [pubmed]
PHST- 2005/07/13 09:00 [medline]
PHST- 2005/03/02 09:00 [entrez]
AID - JST.JSTAGE/yakushi/125.231 [pii]
AID - 10.1248/yakushi.125.231 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2005 Mar;125(3):231-54. doi: 10.1248/yakushi.125.231.