PMID- 15738838
OWN - NLM
STAT- MEDLINE
DCOM- 20050929
LR  - 20191109
IS  - 0398-0499 (Print)
IS  - 0398-0499 (Linking)
VI  - 29
IP  - 5
DP  - 2004 Dec
TI  - [Superficial thrombophlebitis in non varicose veins of the lower limbs. A 
      prospective analysis in 42 patients].
PG  - 263-72
AB  - Recent publications allow better understanding of superficial thrombophlebitis 
      (ST) of the lower limb veins. However ST occurring in non varicose veins (NVV) 
      and those occurring in varicose veins (VV) are seldom distinguished in 
      literature. AIMS OF THE STUDY: 1) To estimate the potential gravity of ST 
      occurring in NVV by putting a figure on the frequency of associated deep venous 
      thrombosis (DVT) and symptomatic pulmonary embolism (PE); 2) to identify some 
      risk factors (thrombophilia, systemic disease, thromboembolic events); 3) to 
      assess the different types of thromboembolic recurrent events after superficial 
      thrombophlebitis (TRST) and identify the risk factors for recurrence. MATERIAL 
      AND METHOD: Forty-two cases of ST occurring in NVV were included consecutively 
      and prospectively in this series; TRST possible risk factors were evaluated. 
      Patients were assessed at 1 month and followed up to 3 years. Isolated ST was 
      treated with low-molecular-weight heparin at prophylactic dosage from 15 to 21 
      days and with elastic compression. RESULTS: 1) A DVT was combined in 12 cases 
      (28.6%) located in the calf (n=9) or in the femoro-politeal axis (n=3). One 
      symptomatic PE occurred confirmed by ventilation-perfusion lung scan; 2) The risk 
      factor investigations identified a neoplasm in 2 patients (4.8%), a non neoplasic 
      systemic disease in 4 (9.5%) and a thrombophilia in 20 patients. The most 
      frequent thrombophilia was the heterozygous mutation of coagulation factor V 
      (Leiden); 3) All patients were assessed at 1 month with a clinical examination 
      and Duplex Scanning. We did not identify either new DTV, PE or extension of the 
      previous DVT; 4) 17 TRST were identified in 13 patients. Three patients had 2 
      recurrences; one patient presented a TRST located at 2 different sites. In total 
      8 new ST and 9 DVT were identified. DISCUSSION: The analysis of the literature 
      shows that early complications or combinations (DVT and PE) occur with the same 
      prevalence in NVV and VV groups. A risk factor was identified in 62% of patients 
      in this series (thrombophilia was the most common) and TRST were statistically 
      more frequent in this series than in groups of ST occurring in VV we had 
      previously analyzed. A post-thrombotic syndrome and a DVT associated with the ST 
      were identified as statistically significant risk factors for recurrence. 
      CONCLUSION: ST occurring in NVV, although representing 5 to 10% of all ST, is 
      seldom reported in the literature. Like ST occurring in VV, they have a potential 
      gravity (associated DVT and PE). However these two diseases should be 
      distinguished. A risk factor is more often identified and TRST are more frequent 
      in the group of ST occurring in NVV. We advise active management of these 
      thromboses including screening for a risk factor, the implementation of measures 
      for preventing venous thrombosis recurrence and patient follow-up.
FAU - Gillet, J L
AU  - Gillet JL
AD  - Cabinet de Medecine Vasculaire, 51 bis Avenue Professeur Tixier, 38300 
      Bourgoin-Jallieu, France.
FAU - Allaert, F A
AU  - Allaert FA
FAU - Perrin, M
AU  - Perrin M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Thromboses veineuses superficielles des veines non variqueuses des membres 
      inferieurs. Etude prospective portant sur 42 patients consecutifs.
PL  - France
TA  - J Mal Vasc
JT  - Journal des maladies vasculaires
JID - 7707965
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Leg/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Thrombophlebitis/*therapy
EDAT- 2005/03/02 09:00
MHDA- 2005/09/30 09:00
CRDT- 2005/03/02 09:00
PHST- 2005/03/02 09:00 [pubmed]
PHST- 2005/09/30 09:00 [medline]
PHST- 2005/03/02 09:00 [entrez]
AID - MDOI-JMV-12-2004-29-5-0398-0499-101019-ART6 [pii]
AID - 10.1016/s0398-0499(04)96771-6 [doi]
PST - ppublish
SO  - J Mal Vasc. 2004 Dec;29(5):263-72. doi: 10.1016/s0398-0499(04)96771-6.