PMID- 15740802
OWN - NLM
STAT- MEDLINE
DCOM- 20050421
LR  - 20131121
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 51
IP  - 4
DP  - 2005 Apr
TI  - Effects of injecting GABAergic agents into the medullary reticular formation upon 
      swallowing induced by the superior laryngeal nerve stimulation in decerebrate 
      cats.
PG  - 395-404
AB  - The purpose of this study was to elucidate the role of the GABAergic system in 
      the medullary reticular formation (MRF) in the control of swallowing. In acutely 
      decerebrated cats (n = 12), swallowing was induced by electrical stimulation 
      (0.3-6 V at 10-20 Hz for 10-20 s every minute) applied to the superior laryngeal 
      nerve (SLN). The stimulus intensity was adjusted so that swallowing was induced 
      two or four times during the period of the stimulation. Bicuculline, a GABA(A) 
      receptor antagonist, was then injected (0.10-0.15 microl, 5 mM) into the MRF 
      through a stereotaxically placed glass micropipette. In a total of 62 injections, 
      19 injections (30.6%) increased the frequency of SLN-induced swallowing when it 
      was injected into the lateral part of the MRF corresponding to the nucleus 
      reticularis parvocellularis (NRPv). In eight of the effective injections (42.1%) 
      which increased the frequency of SLN-induced swallowing, SLN stimulation also 
      induced coughing. With two injections, stimulation of the SLN-induced coughing 
      but not facilitation of swallowing. On the other hand, an injection of 0.10-0.15 
      microl of 5 mM muscimol, a GABA(A) receptor agonist, into the NRPv decreased the 
      frequency of SLN-induced swallowing. These results suggest that the NRPv neurons 
      which are responsible for evoking swallowing are under the tonic inhibitory 
      control of the GABAergic system.
FAU - Harada, Hirofumi
AU  - Harada H
AD  - Department of Physiology, Asahikawa Medical College, Midorigaoka-Higashi 2-1-1-1, 
      Asahikawa 078-8510, Japan.
FAU - Takakusaki, Kaoru
AU  - Takakusaki K
FAU - Kita, Shinichi
AU  - Kita S
FAU - Matsuda, Mitsuyoshi
AU  - Matsuda M
FAU - Nonaka, Satoshi
AU  - Nonaka S
FAU - Sakamoto, Takashi
AU  - Sakamoto T
LA  - eng
PT  - Journal Article
DEP - 20050119
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (GABA Agents)
RN  - 2763-96-4 (Muscimol)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Bicuculline/administration & dosage
MH  - *Brain Mapping
MH  - Cats
MH  - Cough/physiopathology
MH  - Decerebrate State
MH  - Deglutition/*drug effects/physiology
MH  - Electric Stimulation
MH  - Electromyography
MH  - GABA Agents/*administration & dosage
MH  - Gagging/drug effects/physiology
MH  - Injections, Intraventricular
MH  - Laryngeal Nerves/*physiology
MH  - Larynx/physiology
MH  - Microinjections
MH  - Muscimol/administration & dosage
MH  - Pharynx/innervation/physiology
MH  - Reticular Formation/*drug effects/physiology
EDAT- 2005/03/03 09:00
MHDA- 2005/04/22 09:00
CRDT- 2005/03/03 09:00
PHST- 2003/11/14 00:00 [received]
PHST- 2004/12/08 00:00 [revised]
PHST- 2004/12/09 00:00 [accepted]
PHST- 2005/03/03 09:00 [pubmed]
PHST- 2005/04/22 09:00 [medline]
PHST- 2005/03/03 09:00 [entrez]
AID - S0168-0102(04)00312-8 [pii]
AID - 10.1016/j.neures.2004.12.007 [doi]
PST - ppublish
SO  - Neurosci Res. 2005 Apr;51(4):395-404. doi: 10.1016/j.neures.2004.12.007. Epub 
      2005 Jan 19.