PMID- 15740889
OWN - NLM
STAT- MEDLINE
DCOM- 20050809
LR  - 20061115
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 97
IP  - 3
DP  - 2005 Mar 21
TI  - Kurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced 
      chemotaxis.
PG  - 515-9
AB  - The accumulation of circulating monocytes in the arterial wall is an early in 
      atherosclerotic plaque formation. Monocyte chemoattractant protein-1 (MCP-1) 
      promotes the migration of monocytes and would play a role in the development of 
      atherosclerotic lesions. Searching for inhibitors of MCP-1-induced cell migration 
      from natural sources, we isolated one active compound through active-guided 
      fractionations from the MeOH extracts of Sophora flavescens Ait (Leguminosae). On 
      the basis of spectral evidence, the structure of active compound was identified 
      as kurarinone. It inhibited the migration of THP-1 cells induced by MCP-1 with 
      IC50 value of 19.2 microg/mL. In addition, it inhibited the binding of MCP-1 to 
      THP-1 cells and phosphorylation of p42/44 MARK.
FAU - Lee, Seung Woong
AU  - Lee SW
AD  - Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and 
      Biotechnology, 52 Eoun-dong, Taejeon 305-333, Republic of Korea.
FAU - Lee, Hyun Sun
AU  - Lee HS
FAU - Nam, Jung Yeon
AU  - Nam JY
FAU - Kwon, Oh Eok
AU  - Kwon OE
FAU - Baek, Jin Ah
AU  - Baek JA
FAU - Chang, Jong Sun
AU  - Chang JS
FAU - Rho, Mun-Chual
AU  - Rho MC
FAU - Kim, Young Kook
AU  - Kim YK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Flavonoids)
RN  - 0 (Plant Extracts)
RN  - 0 (kurarinone)
SB  - IM
MH  - Cell Line
MH  - *Cell Migration Inhibition
MH  - Chemokine CCL2/*antagonists & inhibitors/*physiology
MH  - Chemotaxis/*drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Flavonoids/chemistry/isolation & purification/*pharmacology
MH  - Humans
MH  - Plant Extracts/chemistry/isolation & purification/pharmacology
MH  - Plant Roots
MH  - *Sophora
EDAT- 2005/03/03 09:00
MHDA- 2005/08/10 09:00
CRDT- 2005/03/03 09:00
PHST- 2004/05/28 00:00 [received]
PHST- 2004/11/18 00:00 [revised]
PHST- 2004/12/07 00:00 [accepted]
PHST- 2005/03/03 09:00 [pubmed]
PHST- 2005/08/10 09:00 [medline]
PHST- 2005/03/03 09:00 [entrez]
AID - S0378-8741(05)00004-8 [pii]
AID - 10.1016/j.jep.2004.12.006 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2005 Mar 21;97(3):515-9. doi: 10.1016/j.jep.2004.12.006.