PMID- 1574117
OWN - NLM
STAT- MEDLINE
DCOM- 19920603
LR  - 20090929
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 356
IP  - 6372
DP  - 1992 Apr 30
TI  - The VASE exon downregulates the neurite growth-promoting activity of NCAM 140.
PG  - 791-3
AB  - Axonal growth, guidance and synapse formation are controlled by receptors on 
      neuronal growth cones that can recognize positive and inhibitory cues in the 
      local microenvironment. Four well characterized receptor systems are known that 
      recognize the growth-promoting activities associated with the extracellular 
      matrix and the membranes of cells such as astrocytes, muscle cells and Schwann 
      cells; these are the integrins and the homophilically binding cell adhesion 
      molecules neural-cell adhesion molecule (NCAM), N-cadherin and L1 (refs 5-12). 
      Alternative splicing generates 20-30 isoforms of NCAM and these can also be 
      differentially glycosylated. There are two sites where alternative splicing 
      changes the extracellular structure of membrane-bound NCAM and one of these (the 
      MSD1 region) does not obviously affect function. Here we report that the variable 
      alternatively spliced exon (VASE) in immunoglobulin domain 4 downregulates the 
      neurite outgrowth-promoting activity of NCAM. The high level of VASE expression 
      in the adult central as compared with peripheral nervous system could contribute 
      to the poor regenerative capacity of the former.
FAU - Doherty, P
AU  - Doherty P
AD  - Department of Experimental Pathology, UMDS, Guy's Hospital, London, UK.
FAU - Moolenaar, C E
AU  - Moolenaar CE
FAU - Ashton, S V
AU  - Ashton SV
FAU - Michalides, R J
AU  - Michalides RJ
FAU - Walsh, F S
AU  - Walsh FS
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Cadherins)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Immunoglobulin Fab Fragments)
RN  - 0 (Sialic Acids)
RN  - 0 (polysialic acid)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Cadherins/physiology
MH  - Cell Adhesion Molecules, Neuronal/*biosynthesis
MH  - Cell Division/drug effects/physiology
MH  - Cells, Cultured
MH  - Down-Regulation/*physiology
MH  - Immunoglobulin Fab Fragments/physiology
MH  - Neurites/*physiology
MH  - Rats
MH  - Sialic Acids/pharmacology
MH  - Transfection
EDAT- 1992/04/30 00:00
MHDA- 1992/04/30 00:01
CRDT- 1992/04/30 00:00
PHST- 1992/04/30 00:00 [pubmed]
PHST- 1992/04/30 00:01 [medline]
PHST- 1992/04/30 00:00 [entrez]
AID - 10.1038/356791a0 [doi]
PST - ppublish
SO  - Nature. 1992 Apr 30;356(6372):791-3. doi: 10.1038/356791a0.