PMID- 15741202
OWN - NLM
STAT- MEDLINE
DCOM- 20050728
LR  - 20071115
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 20
IP  - 5
DP  - 2005 May
TI  - The impact of anaemia and kidney function in congestive heart failure and 
      preserved systolic function.
PG  - 915-9
AB  - BACKGROUND: The importance of anaemia in chronic heart failure was highlighted 
      recently by different cohort studies. The aim of this study was to assess the 
      prevalence of anaemia and its relationship to renal function, left ventricular 
      function and symptoms of heart failure. METHODS: We surveyed cases of patients 
      admitted to the Department of Cardiology during 22 consecutive months. Laboratory 
      measurements, blood pressure and echocardiographic parameters were obtained with 
      standardized methods. RESULTS: Out of a total number of 2941 patients, 238 
      patients (8.1%) had haemoglobin values <11 g/dl. There was a positive association 
      of anaemia with the symptoms of heart failure with a lowering of the median 
      haemoglobin from 14.2 g/dl [New York Heart Association (NYHA) I] to 12.9 g/dl 
      (NYHA IV, P<0.001). Interestingly, anaemia was not associated with left 
      ventricular function or any left ventricular parameters. Symptoms of heart 
      failure, however, were associated with kidney function. The estimated glomerular 
      filtration rate (GFR) was 82 ml/min at NYHA I and 59 ml/min at NYHA IV, P<0.05. 
      There was an association between impaired renal function and haemoglobin values. 
      Haemoglobin was 14.2 g/dl in the group with normal renal function and 11.1 g/dl 
      in the group with a GFR <25 ml/min (P<0.001). Even in patients with normal renal 
      function (878 patients, GFR >85 ml/min), we still found an association of anaemia 
      with the symptoms of heart failure. Haemoglobin was 14.5 g/dl at NYHA I and 13.4 
      g/dl at NYHA IV, P<0.0001. CONCLUSION: Anaemia is found in 8.1% of patients 
      admitted to cardiology service. Anaemia was clearly associated with symptoms of 
      congestive heart failure even in patients with normal renal function. Anaemia was 
      not associated with left ventricular function.
FAU - Philipp, Sebastian
AU  - Philipp S
AD  - Department of Cardiology, Campus Buch and Virchow, Charite, Humboldt University, 
      Berlin, Germany.
FAU - Ollmann, Henrike
AU  - Ollmann H
FAU - Schink, Tania
AU  - Schink T
FAU - Dietz, Rainer
AU  - Dietz R
FAU - Luft, Friedrich C
AU  - Luft FC
FAU - Willenbrock, Roland
AU  - Willenbrock R
LA  - eng
PT  - Journal Article
DEP - 20050301
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
SB  - IM
MH  - Aged
MH  - Anemia/epidemiology/*physiopathology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Heart Failure/*blood/*physiopathology
MH  - Humans
MH  - Kidney/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - *Systole
MH  - Ventricular Function, Left
EDAT- 2005/03/03 09:00
MHDA- 2005/07/29 09:00
CRDT- 2005/03/03 09:00
PHST- 2005/03/03 09:00 [pubmed]
PHST- 2005/07/29 09:00 [medline]
PHST- 2005/03/03 09:00 [entrez]
AID - gfh753 [pii]
AID - 10.1093/ndt/gfh753 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2005 May;20(5):915-9. doi: 10.1093/ndt/gfh753. Epub 2005 
      Mar 1.