PMID- 15744462
OWN - NLM
STAT- MEDLINE
DCOM- 20050809
LR  - 20181113
IS  - 1383-875X (Print)
IS  - 1383-875X (Linking)
VI  - 12
IP  - 2
DP  - 2005 Mar
TI  - Ventricular reverse remodeling and 6-month outcomes in patients receiving cardiac 
      resynchronization therapy: analysis of the MIRACLE study.
PG  - 107-13
AB  - OBJECTIVE: The objective of this analysis was to determine if there were 
      differences in ventricular reverse remodeling and 6-month outcome with cardiac 
      resynchronization therapy (CRT) among specific subgroups enrolled in the 
      Multicenter InSync Randomized Clinical Evaluation (MIRACLE) Study. BACKGROUND: 
      Analysis of major subgroups receiving CRT is important in determining who may be 
      most likely to benefit, since all patients who receive CRT do not demonstrate 
      improvement. METHODS: Differences in response to CRT between subgroups based on 
      baseline echocardiographic parameters, New York Heart Association (NYHA) class, 
      age, gender, beta blocker use, and etiology of heart failure (HF) were analyzed 
      for the clinical end points of the study as well as 6-month HF re-hospitalization 
      or death. RESULTS: The benefit of CRT over control was similar in all subgroups 
      with respect to all clinical endpoints. However, non-ischemic HF patients had 
      greater improvements with CRT compared to ischemic HF patients in left 
      ventricular end diastolic volume (P < 0.001) and ejection fraction (EF) (6.7% 
      increase vs. 3.2% [P < 0.001]). Greater improvements in EF were also seen in 
      those patients with less severe baseline mitral regurgitation (MR) (P < 0.001). 
      Women but not men receiving CRT were more likely to be event-free from first HF 
      hospitalization or death compared to the control group (Hazard Ratio = 0.157). 
      CONCLUSIONS: The benefits of CRT with respect to EF and reverse remodeling were 
      greater in patients with non-ischemic HF and less severe MR. Women may also 
      derive more benefit than men with respect to the occurrence of HF hospitalization 
      or death.
FAU - Woo, Gregory W
AU  - Woo GW
AD  - Division of Cardiovascular Diseases, Department of Medicine, University of 
      Florida, Gainesville, FL 32610, USA. woogw@hotmail.com
FAU - Petersen-Stejskal, Susan
AU  - Petersen-Stejskal S
FAU - Johnson, James W
AU  - Johnson JW
FAU - Conti, Jamie B
AU  - Conti JB
FAU - Aranda, Juan A Jr
AU  - Aranda JA Jr
FAU - Curtis, Anne B
AU  - Curtis AB
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - Netherlands
TA  - J Interv Card Electrophysiol
JT  - Journal of interventional cardiac electrophysiology : an international journal of 
      arrhythmias and pacing
JID - 9708966
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - *Cardiac Pacing, Artificial
MH  - *Defibrillators, Implantable
MH  - Echocardiography
MH  - *Electric Countershock
MH  - Female
MH  - Heart Failure/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Quality of Life
MH  - Statistics, Nonparametric
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left
MH  - Ventricular Remodeling/*physiology
EDAT- 2005/03/04 09:00
MHDA- 2005/08/10 09:00
CRDT- 2005/03/04 09:00
PHST- 2004/10/19 00:00 [received]
PHST- 2004/11/05 00:00 [accepted]
PHST- 2005/03/04 09:00 [pubmed]
PHST- 2005/08/10 09:00 [medline]
PHST- 2005/03/04 09:00 [entrez]
AID - 10.1007/s10840-005-6545-3 [doi]
PST - ppublish
SO  - J Interv Card Electrophysiol. 2005 Mar;12(2):107-13. doi: 
      10.1007/s10840-005-6545-3.