PMID- 15749199 OWN - NLM STAT- MEDLINE DCOM- 20050616 LR - 20061115 IS - 0167-5273 (Print) IS - 0167-5273 (Linking) VI - 99 IP - 2 DP - 2005 Mar 18 TI - Hypoxia inducible factor-1 expression mediates myocardial response to ischemia late after acute myocardial infarction. PG - 337-9 AB - We report hypoxia-inducible factor-1 (HIF-1) expression in myocardium of patients with recent acute myocardial infarction (AMI), supporting the hypothesis of HIF-1 as a possible mediator of response to ischemia. A potential diagnostic role of determining tissue expression of HIF-1 as a marker of ischemia, and potential therapeutic implications by trying to modulate HIF-1 activity in order to promote beneficial effects of HIF-1 related genes (e.g. expression of vascular endothelial growth factor (VEGF)) may derive. FAU - Parisi, Quintino AU - Parisi Q FAU - Biondi-Zoccai, Giuseppe G L AU - Biondi-Zoccai GG FAU - Abbate, Antonio AU - Abbate A FAU - Santini, Daniele AU - Santini D FAU - Vasaturo, Fortunata AU - Vasaturo F FAU - Scarpa, Susanna AU - Scarpa S FAU - Bussani, Rossana AU - Bussani R FAU - Leone, Antonio Maria AU - Leone AM FAU - Petrolini, Alessandro AU - Petrolini A FAU - Silvestri, Furio AU - Silvestri F FAU - Biasucci, Luigi M AU - Biasucci LM FAU - Baldi, Alfonso AU - Baldi A LA - eng PT - Comparative Study PT - Letter PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 RN - 0 (DNA-Binding Proteins) RN - 0 (HIF1A protein, human) RN - 0 (Hif1a protein, rat) RN - 0 (Hypoxia-Inducible Factor 1) RN - 0 (Hypoxia-Inducible Factor 1, alpha Subunit) RN - 0 (Nuclear Proteins) RN - 0 (Transcription Factors) SB - IM MH - Aged MH - Animals MH - Cadaver MH - DNA-Binding Proteins/*biosynthesis MH - Disease Models, Animal MH - Female MH - Gene Expression/*physiology MH - Humans MH - Hypoxia-Inducible Factor 1 MH - Hypoxia-Inducible Factor 1, alpha Subunit MH - Male MH - Myocardial Infarction/*metabolism/pathology MH - Myocardium/*metabolism/pathology MH - Myocytes, Cardiac/metabolism/pathology MH - Nuclear Proteins/*biosynthesis MH - Rats MH - Rats, Sprague-Dawley MH - Time Factors MH - Transcription Factors/*biosynthesis EDAT- 2005/03/08 09:00 MHDA- 2005/06/17 09:00 CRDT- 2005/03/08 09:00 PHST- 2003/08/30 00:00 [received] PHST- 2003/11/16 00:00 [accepted] PHST- 2005/03/08 09:00 [pubmed] PHST- 2005/06/17 09:00 [medline] PHST- 2005/03/08 09:00 [entrez] AID - S0167527304001524 [pii] AID - 10.1016/j.ijcard.2003.11.038 [doi] PST - ppublish SO - Int J Cardiol. 2005 Mar 18;99(2):337-9. doi: 10.1016/j.ijcard.2003.11.038.