PMID- 15749498
OWN - NLM
STAT- MEDLINE
DCOM- 20050505
LR  - 20220408
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 83
IP  - 3
DP  - 2005 Mar
TI  - Antiphospholipid antibodies associated with recurrent pregnancy loss: 
      prospective, multicenter, controlled pilot study comparing treatment with 
      low-molecular-weight heparin versus unfractionated heparin.
PG  - 684-90
AB  - OBJECTIVE: To evaluate the use of low-molecular-weight heparin (LMWH) in 
      combination with low-dose aspirin (LDA) for the treatment of antiphospholipid 
      antibody (APA)-associated recurrent pregnancy loss and to compare the results 
      with the use of unfractionated heparin (UFH) plus LDA. DESIGN: Prospective, 
      controlled, multicenter pilot study. SETTING: Two academically based reproductive 
      health centers. PATIENT(S): Patients with three or more pregnancy losses and 
      positive APA. INTERVENTION(S): Patients were treated with LMWH and LDA (n = 25) 
      or UFH and LDA (n = 25). MAIN OUTCOME MEASURE(S): Fetal outcome and maternal 
      complications from treatments were compared between the two treatment groups. 
      RESULT(S): Of the 25 patients in the LMWH group, 21 (84%) delivered a viable 
      infant and 4 (16%) miscarried. Of the 25 patients in the UFH group, 20 (80%) 
      delivered a viable infant and 5 (20%) miscarried. These differences were not 
      statistically significant. No major bleeding episodes occurred during pregnancy 
      or at the time of delivery. No cases of deep venous thrombosis, thrombocytopenia, 
      pre-eclampsia, gestational diabetes, or bone fractures were noted in either of 
      the two groups. CONCLUSION(S): In this pilot study, the use of LDA in combination 
      with LMWH during pregnancy for the prevention of recurrent pregnancy loss in 
      women with antiphospholipid syndrome seems to be as safe as UFH plus LDA. Large, 
      randomized trials will be required to determine differences in outcome with LMWH 
      and LDA compared with treatment with UFH combined with LDA in this group of 
      patients.
FAU - Noble, Luis S
AU  - Noble LS
AD  - Department of Obstetrics, Texas Tech University Health Sciences Center, El Paso, 
      Texas, USA.
FAU - Kutteh, William H
AU  - Kutteh WH
FAU - Lashey, Nanette
AU  - Lashey N
FAU - Franklin, Rodney D
AU  - Franklin RD
FAU - Herrada, Juan
AU  - Herrada J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Abortion, Habitual/*immunology/*prevention & control
MH  - Adult
MH  - Antibodies, Antiphospholipid/*blood
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - Aspirin/administration & dosage/adverse effects
MH  - Drug Therapy, Combination
MH  - Female
MH  - Heparin, Low-Molecular-Weight/*administration & dosage/adverse effects
MH  - Humans
MH  - Pilot Projects
MH  - Platelet Aggregation Inhibitors/administration & dosage/adverse effects
MH  - Pregnancy
MH  - Pregnancy Complications/immunology/prevention & control
MH  - Pregnancy Outcome
MH  - Premature Birth
MH  - Prospective Studies
EDAT- 2005/03/08 09:00
MHDA- 2005/05/06 09:00
CRDT- 2005/03/08 09:00
PHST- 2004/05/20 00:00 [received]
PHST- 2004/08/12 00:00 [revised]
PHST- 2004/08/12 00:00 [accepted]
PHST- 2005/03/08 09:00 [pubmed]
PHST- 2005/05/06 09:00 [medline]
PHST- 2005/03/08 09:00 [entrez]
AID - S0015-0282(04)02983-8 [pii]
AID - 10.1016/j.fertnstert.2004.11.002 [doi]
PST - ppublish
SO  - Fertil Steril. 2005 Mar;83(3):684-90. doi: 10.1016/j.fertnstert.2004.11.002.