PMID- 15749929
OWN - NLM
STAT- MEDLINE
DCOM- 20050823
LR  - 20181201
IS  - 1066-5099 (Print)
IS  - 1066-5099 (Linking)
VI  - 23
IP  - 3
DP  - 2005 Mar
TI  - Macrophage colony-stimulating factor (M-CSF), as well as granulocyte 
      colony-stimulating factor (G-CSF), accelerates neovascularization.
PG  - 347-54
AB  - It has been reported that bone marrow cells (BMCs) differentiate into endothelial 
      cells of blood vessels, and that granulocyte colony-stimulating factor (G-CSF) 
      mobilizes progenitors in the BMCs to the peripheral blood, while macrophage 
      colony-stimulating factor (M-CSF) augments the production of monocytes. We 
      examined whether M-CSF augments the differentiation of BMCs into endothelial 
      cells of blood vessels using a hindlimb-ischemic model. Either G-CSF or M-CSF, or 
      both, was administered to the hindlimb-ischemic mice for 3 days. Both M-CSF and 
      G-CSF augmented the differentiation of BMCs into endothelial cells of blood 
      vessels through vascular endothelial cell growth factor (VEGF), resulting in 
      early recovery of blood flow in the ischemic limbs.
FAU - Minamino, Keizo
AU  - Minamino K
AD  - First Department of Pathology, Kansai Medical University, Moriguchi, Osaka 
      570-8507, Japan.
FAU - Adachi, Yasushi
AU  - Adachi Y
FAU - Okigaki, Mitsuhiko
AU  - Okigaki M
FAU - Ito, Hidefumi
AU  - Ito H
FAU - Togawa, Yoshimi
AU  - Togawa Y
FAU - Fujita, Kengo
AU  - Fujita K
FAU - Tomita, Minoru
AU  - Tomita M
FAU - Suzuki, Yasuhiro
AU  - Suzuki Y
FAU - Zhang, Yuming
AU  - Zhang Y
FAU - Iwasaki, Masayoshi
AU  - Iwasaki M
FAU - Nakano, Keiji
AU  - Nakano K
FAU - Koike, Yasushi
AU  - Koike Y
FAU - Matsubara, Hiroaki
AU  - Matsubara H
FAU - Iwasaka, Toshiji
AU  - Iwasaka T
FAU - Matsumura, Miyo
AU  - Matsumura M
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (H-2 Antigens)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (vascular endothelial growth factor A, mouse)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*drug effects/metabolism
MH  - Bone Marrow Transplantation
MH  - Cell Differentiation/*drug effects
MH  - Cell Proliferation/drug effects
MH  - Endothelium/chemistry
MH  - Granulocyte Colony-Stimulating Factor/*pharmacology
MH  - Green Fluorescent Proteins/genetics/metabolism
MH  - H-2 Antigens/analysis
MH  - Hindlimb/blood supply/drug effects/pathology
MH  - Ischemia/physiopathology
MH  - Macrophage Colony-Stimulating Factor/*pharmacology
MH  - Mesenchymal Stem Cells/cytology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Muscle, Skeletal/blood supply
MH  - Neovascularization, Physiologic/*drug effects
MH  - Regional Blood Flow/drug effects
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2005/03/08 09:00
MHDA- 2005/08/24 09:00
CRDT- 2005/03/08 09:00
PHST- 2005/03/08 09:00 [pubmed]
PHST- 2005/08/24 09:00 [medline]
PHST- 2005/03/08 09:00 [entrez]
AID - 23/3/347 [pii]
AID - 10.1634/stemcells.2004-0190 [doi]
PST - ppublish
SO  - Stem Cells. 2005 Mar;23(3):347-54. doi: 10.1634/stemcells.2004-0190.