PMID- 15750761
OWN - NLM
STAT- MEDLINE
DCOM- 20050504
LR  - 20050307
IS  - 0300-8126 (Print)
IS  - 0300-8126 (Linking)
VI  - 33
IP  - 1
DP  - 2005 Feb
TI  - Immune reconstitution inflammatory syndrome (IRIS)--another new disease entity 
      following treatment initiation of HIV infection.
PG  - 43-5
AB  - After the introduction of highly active antiretroviral therapy (HAART) in 1995 it 
      took 3 years to recognize the new syndrome of lipodystrophy as a long-term 
      complication of HAART [1]. It was found to be a direct toxic consequence of the 
      various drugs used in combination regimens. Another 2 years later, an additional 
      syndrome was described in patients who recently initiated HAART-the immune 
      reconstitution inflammatory syndrome (IRIS) [2-4]. Although already recognized in 
      the pre-HIV era in patients with treatment for tuberculosis [5, 6] and leprosy 
      [7], it became substantially more frequent in HIV-infected patients on HAART. The 
      term IRIS describes a collection of different inflammatory disorders which are 
      associated with paradoxical deterioration of various preexisting infectious 
      processes following commencement of HAART in HIV-infected patients. These 
      preexisting infections in individuals with IRIS may have been previously 
      diagnosed and treated or may have been symptomless and later revealed by the 
      patient's improved capacity to mount an inflammatory response.
FAU - Goebel, F D
AU  - Goebel FD
AD  - Dept. of Infectious Diseases, Medical Policlinic, Ludwig Maximilian University 
      Munich, Pettenkoferstrasse 8a, D-80336 Munich, Germany. 
      Frank.Goebel@med.uni-muenchen.de
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Infection
JT  - Infection
JID - 0365307
SB  - IM
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - HIV Infections/*drug therapy/*immunology
MH  - Humans
MH  - Inflammation/*chemically induced/*immunology
MH  - Syndrome
EDAT- 2005/03/08 09:00
MHDA- 2005/05/05 09:00
CRDT- 2005/03/08 09:00
PHST- 2005/03/08 09:00 [pubmed]
PHST- 2005/05/05 09:00 [medline]
PHST- 2005/03/08 09:00 [entrez]
AID - 10.1007/s15010-005-6105-x [doi]
PST - ppublish
SO  - Infection. 2005 Feb;33(1):43-5. doi: 10.1007/s15010-005-6105-x.