PMID- 15752581
OWN - NLM
STAT- MEDLINE
DCOM- 20050808
LR  - 20210502
IS  - 0196-9781 (Print)
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 26
IP  - 4
DP  - 2005 Apr
TI  - Central vagal stimulation activates enteric cholinergic neurons in the stomach 
      and VIP neurons in the duodenum in conscious rats.
PG  - 653-64
AB  - The influence of central vagal stimulation induced by 2h cold exposure or 
      intracisternal injection of thyrotropin-releasing hormone (TRH) analog, RX-77368, 
      on gastro-duodenal enteric cholinergic neuronal activity was assessed in 
      conscious rats with Fos and peripheral choline acetyltransferase (pChAT) 
      immunoreactivity (IR). pChAT-IR was detected in 68%, 70% and 73% of corpus, 
      antrum and duodenum submucosal neurons, respectively, and in 65% of gastric and 
      46% of duodenal myenteric neurons. Cold and RX-77368 induced Fos-IR in over 90% 
      of gastric submucosal and myenteric neurons, while in duodenum only 25-27% of 
      submucosal and 50-51% myenteric duodenal neurons were Fos positive. In the 
      stomach, cold induced Fos-IR in 93% of submucosal and 97% of myenteric pChAT-IR 
      neurons, while in the duodenum only 7% submucosal and 5% myenteric pChAT-IR 
      neurons were Fos positive. In the duodenum, cold induced Fos in 91% of submucosal 
      and 99% of myenteric VIP-IR neurons. RX-77368 induces similar percentages of 
      Fos/pChAT-IR and Fos/VIP-IR neurons. These results indicate that increased 
      central vagal outflow activates cholinergic neurons in the stomach while in the 
      duodenum, VIP neurons are preferentially stimulated.
FAU - Yuan, Pu-Qing
AU  - Yuan PQ
AD  - CURE: Digestive Diseases Research Center, VA Greater Los Angeles Healthcare 
      System, Digestive Diseases Division, Department of Medicine and Brain Research 
      Institute, University of California Los Angeles, Los Angeles, CA 90073, USA. 
      pqyuan@ucla.edu
FAU - Kimura, Hiroshi
AU  - Kimura H
FAU - Million, Mulugeta
AU  - Million M
FAU - Bellier, Jean-Pierre
AU  - Bellier JP
FAU - Wang, Lixin
AU  - Wang L
FAU - Ohning, Gordon V
AU  - Ohning GV
FAU - Tache, Yvette
AU  - Tache Y
LA  - eng
GR  - R37 DK033061/DK/NIDDK NIH HHS/United States
GR  - R01 DK-33061/DK/NIDDK NIH HHS/United States
GR  - DK 41301/DK/NIDDK NIH HHS/United States
GR  - R01 DK033061/DK/NIDDK NIH HHS/United States
GR  - P30 DK041301/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050106
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Animals
MH  - Consciousness
MH  - Duodenum/*innervation
MH  - Gastric Mucosa/drug effects/*innervation
MH  - Intestinal Mucosa/drug effects/*innervation
MH  - Male
MH  - Neurons/drug effects/*physiology
MH  - Physical Stimulation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stomach/*innervation
MH  - Thyrotropin/pharmacology
MH  - Vagus Nerve/drug effects/*physiology
PMC - PMC8082755
MID - NIHMS1695036
EDAT- 2005/03/09 09:00
MHDA- 2005/08/09 09:00
PMCR- 2021/04/29
CRDT- 2005/03/09 09:00
PHST- 2004/09/28 00:00 [received]
PHST- 2004/11/12 00:00 [revised]
PHST- 2004/11/17 00:00 [accepted]
PHST- 2005/03/09 09:00 [pubmed]
PHST- 2005/08/09 09:00 [medline]
PHST- 2005/03/09 09:00 [entrez]
PHST- 2021/04/29 00:00 [pmc-release]
AID - S0196-9781(04)00513-3 [pii]
AID - 10.1016/j.peptides.2004.11.015 [doi]
PST - ppublish
SO  - Peptides. 2005 Apr;26(4):653-64. doi: 10.1016/j.peptides.2004.11.015. Epub 2005 
      Jan 6.