PMID- 15753633
OWN - NLM
STAT- MEDLINE
DCOM- 20050531
LR  - 20151119
IS  - 0025-7931 (Print)
IS  - 0025-7931 (Linking)
VI  - 72
IP  - 1
DP  - 2005 Jan-Feb
TI  - Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients 
      with idiopathic nonspecific interstitial pneumonia.
PG  - 39-45
AB  - BACKGROUND: Interleukin-18 (IL-18) is a proinflammatory cytokine that can induce 
      interferon-gamma (IFN-gamma), and it plays an important role in T-helper 1 
      responses. Among idiopathic interstitial pneumonia (IIP), nonspecific 
      interstitial pneumonia (NSIP) has an increased number of lymphocytes in 
      bronchoalveolar lavage (BAL) fluid compared with usual interstitial pneumonia 
      (UIP). However, the difference in their pathogenesis is unclear. OBJECTIVE: The 
      present study aims to investigate the roles of IL-18 in patients with idiopathic 
      UIP and idiopathic NSIP. METHODS: We measured the serum and BAL fluid (BALF) 
      levels of IL-18 and IFN-gamma in 22 patients with IIP (12 with UIP, 10 with NSIP) 
      and 9 healthy volunteers. RESULTS: Lymphocyte proportions in BALF were 
      significantly higher in NSIP than in UIP and healthy subjects. No significant 
      differences were observed in the serum IL-18 levels of all subjects, while the 
      BALF levels of IL-18 in patients with NSIP were significantly higher than in 
      patients with UIP (p < 0.005) and in healthy subjects (p < 0.005). Among all 
      subjects, the levels of IL-18 in BALF correlated significantly with those in 
      serum and the lymphocyte proportions in BALF. The serum IFN-gamma levels of all 
      subjects were below sensitivity, but there was significant reverse correlation 
      between the levels of IFN-gamma and the lymphocyte proportions in BALF. 
      CONCLUSION: The lymphocytosis in BALF of patients with idiopathic NSIP and a part 
      of idiopathic UIP might be associated with the high levels of IL-18.
CI  - Copyright (c) 2005 S. Karger AG, Basel.
FAU - Ishii, Hiroshi
AU  - Ishii H
AD  - Second Department of Internal Medicine, Nagasaki University School of Medicine, 
      Nagasaki, Japan.
FAU - Mukae, Hiroshi
AU  - Mukae H
FAU - Kadota, Jun-ichi
AU  - Kadota J
FAU - Fujii, Takeshi
AU  - Fujii T
FAU - Abe, Koh
AU  - Abe K
FAU - Ashitani, Jun-ichi
AU  - Ashitani J
FAU - Kohno, Shigeru
AU  - Kohno S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
RN  - 0 (Antigens)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers)
RN  - 0 (Glycoproteins)
RN  - 0 (Interleukin-18)
RN  - 0 (MUC1 protein, human)
RN  - 0 (Mucin-1)
RN  - 0 (Mucins)
RN  - 0 (Pulmonary Surfactant-Associated Protein A)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
CIN - Respiration. 2005 Jan-Feb;72(1):28-9. PMID: 15753630
MH  - Adult
MH  - Aged
MH  - Antigens/blood
MH  - Antigens, Neoplasm
MH  - Biomarkers/metabolism
MH  - Biopsy
MH  - Bronchoalveolar Lavage Fluid/*cytology/immunology
MH  - CD4-CD8 Ratio
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Eosinophils/cytology
MH  - Female
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique, Direct
MH  - Glycoproteins/blood
MH  - Humans
MH  - Interferon-gamma/metabolism
MH  - Interleukin-18/immunology/*metabolism
MH  - Lung Diseases, Interstitial/immunology/*metabolism/pathology
MH  - Lymphocytosis/*immunology/pathology
MH  - Macrophages, Alveolar/cytology/immunology
MH  - Male
MH  - Middle Aged
MH  - Mucin-1
MH  - Mucins
MH  - Neutrophils/cytology
MH  - Pulmonary Surfactant-Associated Protein A/blood
EDAT- 2005/03/09 09:00
MHDA- 2005/06/01 09:00
CRDT- 2005/03/09 09:00
PHST- 2003/07/22 00:00 [received]
PHST- 2004/06/07 00:00 [accepted]
PHST- 2005/03/09 09:00 [pubmed]
PHST- 2005/06/01 09:00 [medline]
PHST- 2005/03/09 09:00 [entrez]
AID - 83399 [pii]
AID - 10.1159/000083399 [doi]
PST - ppublish
SO  - Respiration. 2005 Jan-Feb;72(1):39-45. doi: 10.1159/000083399.