PMID- 15753650
OWN - NLM
STAT- MEDLINE
DCOM- 20051020
LR  - 20200930
IS  - 1538-4047 (Print)
IS  - 1538-4047 (Linking)
VI  - 4
IP  - 2
DP  - 2005 Feb
TI  - Analysis of chromosomes 9 and 11 aneuploidy frequency in pleural effusion of 
      patients with and without malignancy: interphase FISH technique.
PG  - 248-51
AB  - Fluids of body cavities result in a series of pathophysiological events 
      associated with non-malignant and malignant conditions that lead to the formation 
      of exudative effusion. Diagnosis of effusion from the patients is frequently 
      troublesome for the cytologist because of the differentiation and biological 
      behavior of different cells type in effusion. In the present study, chromosomal 
      aneuploidy status in effusion cells derived from 32 patients including 14 
      patients with non-malignant and 18 patients with malignant diseases [including 
      malign mesothelioma (n = 6), adeno carcinoma (n = 10), small cell carcinoma (n = 
      2)] was analyzed by using fluorescence in situ hybridization (FISH) with 
      centromere specific probes for chromosomes 9 and 11. There was significant 
      difference in the incidence of chromosomal 9 and 11 aneuploidies when compared 
      with controls (P = 0.000). However, aneuploidies of chromosomes 9 and 11 in 
      effusion cells from patients with malignant disease had significantly higher than 
      in effusion cells from patients with non-malignant (P = 0.000), suggesting that 
      chromosomes 9 and 11 are frequently involved in the status of disease. The 
      present study indicates that there is a association between chromosomes 
      aneuploidies and pleural effusion cell status. Chromosome aneuploidies in 
      non-malignant group may be an indicator of premalignancy.
FAU - Cora, Tulin
AU  - Cora T
AD  - Department of Medical Genetics, Sekuk University, Medical Faculty, Konya,Turkey. 
      yaseminsena@hotmail.com
FAU - Acar, Hasan
AU  - Acar H
FAU - Ceran, Sami
AU  - Ceran S
FAU - Bodur, Said
AU  - Bodur S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050303
PL  - United States
TA  - Cancer Biol Ther
JT  - Cancer biology & therapy
JID - 101137842
SB  - IM
MH  - Adenocarcinoma/genetics/pathology
MH  - Aneuploidy
MH  - Ascites/*pathology
MH  - Carcinoma, Small Cell/genetics/pathology
MH  - Case-Control Studies
MH  - Centromere
MH  - Chromosome Mapping
MH  - *Chromosomes, Human
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Interphase
MH  - Male
MH  - Mesothelioma/genetics/pathology
MH  - Neoplasms/*genetics/pathology
MH  - Pleural Effusion/*pathology
EDAT- 2005/03/09 09:00
MHDA- 2005/10/21 09:00
CRDT- 2005/03/09 09:00
PHST- 2005/03/09 09:00 [pubmed]
PHST- 2005/10/21 09:00 [medline]
PHST- 2005/03/09 09:00 [entrez]
AID - 1573 [pii]
AID - 10.4161/cbt.4.2.1573 [doi]
PST - ppublish
SO  - Cancer Biol Ther. 2005 Feb;4(2):248-51. doi: 10.4161/cbt.4.2.1573. Epub 2005 Mar 
      3.