PMID- 15754014
OWN - NLM
STAT- MEDLINE
DCOM- 20050804
LR  - 20061115
IS  - 1107-3756 (Print)
IS  - 1107-3756 (Linking)
VI  - 15
IP  - 4
DP  - 2005 Apr
TI  - Evolution of interleukin-18 binding proteins and interleukin-1 receptor, type II 
      proteins.
PG  - 561-6
AB  - Interleukin-18 (IL-18) is one of the pivotal cytokines controlling the defense 
      mechanism called inflammation. As a first step to develop proteins for 
      controlling the IL-18 level, we initiated a study of IL-18-binding proteins 
      (IL-18BPs). Twenty-four IL-18BP family members, 11 from vertebrates and 13 from 
      chordopoxviruses, were picked from the NCBI database. Eight of these vertebrate 
      IL-18BPs and two of the chordopoxvirus IL18-BPs were identified here and 
      characterized as new members of the IL-18BP family. Their IL-18 binding domains 
      were aligned and the distribution of highly conserved critical amino acid 
      residues was analyzed and used to construct a phylogenetic tree. From this tree 
      it was inferred that at least two independent events created two different 
      ancestral viral IL-18BP genes by retroposition of IL-18BP genes from the 
      vertebrate lineage. These two events are estimated to have occurred after an 
      ancient mammalian IL-18BP gene diverged from birds, and before the mammalian 
      IL-18BP gene diverged into human, ungulate and rodent IL-18BP genes. Moreover, 
      our results suggest that IL-18BP and interleukin-1 receptor, type II (IL-1R2) had 
      a common ancestral gene and diverged from the ancestral gene into IL-18BP and 
      IL-1R2 genes in the fish period.
FAU - Watanabe, Makoto
AU  - Watanabe M
AD  - Hirakata Ryoikuen, Hirakata, Osaka 573-0122, Japan.
FAU - Goto, Naohisa
AU  - Goto N
FAU - Watanabe, Yuko
AU  - Watanabe Y
FAU - Nishiguchi, Seiji
AU  - Nishiguchi S
FAU - Shimada, Kazunori
AU  - Shimada K
FAU - Yasunga, Teruo
AU  - Yasunga T
FAU - Yamanishi, Hiromichi
AU  - Yamanishi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Glycoproteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Receptors, Interleukin-1 Type II)
RN  - 0 (interleukin-18 binding protein)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - *Evolution, Molecular
MH  - Glycoproteins/*genetics
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins
MH  - Molecular Sequence Data
MH  - Protein Structure, Tertiary
MH  - Receptors, Interleukin-1/*genetics
MH  - Receptors, Interleukin-1 Type II
EDAT- 2005/03/09 09:00
MHDA- 2005/08/05 09:00
CRDT- 2005/03/09 09:00
PHST- 2005/03/09 09:00 [pubmed]
PHST- 2005/08/05 09:00 [medline]
PHST- 2005/03/09 09:00 [entrez]
PST - ppublish
SO  - Int J Mol Med. 2005 Apr;15(4):561-6.