PMID- 15754038
OWN - NLM
STAT- MEDLINE
DCOM- 20050804
LR  - 20201209
IS  - 1107-3756 (Print)
IS  - 1107-3756 (Linking)
VI  - 15
IP  - 4
DP  - 2005 Apr
TI  - Identification and characterization of a novel human nephronectin gene in silico.
PG  - 719-24
AB  - We describe the identification and characterization of a human epidermal growth 
      factor (EGF)-like gene, nephronectin (NPNT), which encodes predicted proteins 
      most homologous to the mouse nephronectin (Npnt). Human NPNT is located at the 
      chromosomal position 4q25. Two transcript variants, NPNTa and NPNTb, are 
      identified. Sequence comparison indicated that the human NPNT proteins share 88% 
      amino acid identity with their mouse homologs. The in silico expression analysis 
      showed the NPNT expression in a number of embryonic and adult tissues. NPNT was 
      expressed in fetal ear, eye, heart, lung and kidney. In adults, the NPNT 
      expression was widely found in lung, kidney, brain, uterus, placenta, thyroid 
      gland and blood vessels. This gene is therefore implicated in embryonic 
      development as well as maintenance of various adult tissues.
FAU - Huang, Jeffrey T-J
AU  - Huang JT
AD  - Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK. 
      jeffrey.huang@bbsrc.ac.uk
FAU - Lee, Vivian
AU  - Lee V
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (EGFL6 protein, human)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Peptides)
RN  - 0 (nephronectin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Calcium-Binding Proteins
MH  - Cell Adhesion Molecules
MH  - Chromosome Mapping
MH  - *Computational Biology
MH  - Extracellular Matrix Proteins/*genetics/metabolism
MH  - Glycoproteins/genetics
MH  - Humans
MH  - Membrane Glycoproteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/genetics
MH  - Peptides/genetics
EDAT- 2005/03/09 09:00
MHDA- 2005/08/05 09:00
CRDT- 2005/03/09 09:00
PHST- 2005/03/09 09:00 [pubmed]
PHST- 2005/08/05 09:00 [medline]
PHST- 2005/03/09 09:00 [entrez]
PST - ppublish
SO  - Int J Mol Med. 2005 Apr;15(4):719-24.