PMID- 15755587
OWN - NLM
STAT- MEDLINE
DCOM- 20050518
LR  - 20171116
IS  - 0264-410X (Print)
IS  - 0264-410X (Linking)
VI  - 23
IP  - 17-18
DP  - 2005 Mar 18
TI  - Antigenic complementarity between HIV and other AIDS-associated infections 
      results in idiotype-antiidiotype antibody complexes that cross react with 
      lymphocyte proteins.
PG  - 2160-3
AB  - HIV proteins mimic HLA proteins, and the proteins of cofactor infections 
      (cytomegalovirus, hepatitis viruses, mycobacteria, mycoplasmas) mimic CD4 
      proteins, making some HIV antigens molecularly complementary to cofactor 
      antigens. Antibodies to HIV and its cofactors should therefore act like 
      idiotype-antiidiotype pairs. Over 2000 combinations of antibodies were tested for 
      such complementarity using modified forms of Ouchterlony immunodiffusion and 
      ELISA. HIV antibodies do precipitate some antibodies against cofactor infections 
      including CMV, HBV, mycobacteria and mycoplasmas. These antibodies also mimic 
      antibodies against HLA and CD4 proteins. Thus, some combinations of HIV with 
      cofactor infections may induce lymphocytotoxic antibodies (LCTA), a risk that 
      must be addressed in vaccine development.
FAU - Root-Bernstein, Robert
AU  - Root-Bernstein R
AD  - Department of Physiology, 2174 Biomedical and Physical Sciences Building, 
      Michigan State University, East Lansing, MI 48824, USA. rootbern@msu.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (CD4 Antigens)
RN  - 0 (HIV Antibodies)
RN  - 0 (HIV Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*immunology
MH  - Amino Acid Sequence
MH  - Antibodies, Anti-Idiotypic/chemistry
MH  - Antigen-Antibody Complex/chemistry
MH  - Antilymphocyte Serum/chemistry
MH  - Autoimmunity
MH  - CD4 Antigens/genetics
MH  - Cross Reactions
MH  - HIV Antibodies/chemistry
MH  - HIV Antigens/genetics
MH  - HIV Infections/*immunology
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Models, Immunological
MH  - Molecular Mimicry
MH  - Molecular Sequence Data
EDAT- 2005/03/10 09:00
MHDA- 2005/05/19 09:00
CRDT- 2005/03/10 09:00
PHST- 2005/03/10 09:00 [pubmed]
PHST- 2005/05/19 09:00 [medline]
PHST- 2005/03/10 09:00 [entrez]
AID - S0264-410X(05)00052-6 [pii]
AID - 10.1016/j.vaccine.2005.01.049 [doi]
PST - ppublish
SO  - Vaccine. 2005 Mar 18;23(17-18):2160-3. doi: 10.1016/j.vaccine.2005.01.049.