PMID- 15755660
OWN - NLM
STAT- MEDLINE
DCOM- 20050901
LR  - 20131121
IS  - 0968-0896 (Print)
IS  - 0968-0896 (Linking)
VI  - 13
IP  - 7
DP  - 2005 Apr 1
TI  - Inhibitory activity of a ceramide library on interleukin-4 production from 
      activated T cells.
PG  - 2589-95
AB  - Allergic diseases are hypersensitivity disorders associated with the production 
      of specific immunoglobulin E (IgE) to environmental allergens. Interleukin 
      (IL)-4, produced primarily by CD4(+) T cells, is an important stimulus for the 
      switch of the antibody isotype to IgE in both mice and humans. In this study we 
      investigated the inhibitory activity of IL-4 production in activated T cells by 
      screening ceramide derivatives prepared by solid phase combinatorial chemistry. 
      Many ceramide derivatives significantly inhibited IL-4 production in T cells. In 
      particular, ceramide derivatives with a lauroyl group showed strong inhibitory 
      activities on IL-4 production in both phorbol 12-myristate 13-acetate 
      (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be 
      used as compounds for the development of anti-allergic agents.
FAU - Park, Jin
AU  - Park J
AD  - Department of Pharmacy, College of Pharmacy, Chonnam National University, Gwangju 
      500-757, Republic of Korea.
FAU - Li, Qian
AU  - Li Q
FAU - Chang, Young-Tae
AU  - Chang YT
FAU - Kim, Tae Sung
AU  - Kim TS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioorg Med Chem
JT  - Bioorganic & medicinal chemistry
JID - 9413298
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Ceramides)
RN  - 0 (RNA, Messenger)
RN  - 207137-56-2 (Interleukin-4)
RN  - 56937-68-9 (phorbolol myristate acetate)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/chemistry/*pharmacology
MH  - CD4-Positive T-Lymphocytes/*drug effects/immunology
MH  - Ceramides/chemistry/*pharmacology
MH  - Combinatorial Chemistry Techniques
MH  - Dose-Response Relationship, Immunologic
MH  - Female
MH  - Interleukin-4/*antagonists & inhibitors/biosynthesis
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Structure
MH  - RNA, Messenger/drug effects/metabolism
MH  - Tetradecanoylphorbol Acetate/analogs & derivatives/pharmacology
MH  - Tumor Cells, Cultured
EDAT- 2005/03/10 09:00
MHDA- 2005/09/02 09:00
CRDT- 2005/03/10 09:00
PHST- 2004/11/13 00:00 [received]
PHST- 2005/01/17 00:00 [revised]
PHST- 2005/01/18 00:00 [accepted]
PHST- 2005/03/10 09:00 [pubmed]
PHST- 2005/09/02 09:00 [medline]
PHST- 2005/03/10 09:00 [entrez]
AID - S0968-0896(05)00053-2 [pii]
AID - 10.1016/j.bmc.2005.01.027 [doi]
PST - ppublish
SO  - Bioorg Med Chem. 2005 Apr 1;13(7):2589-95. doi: 10.1016/j.bmc.2005.01.027.