PMID- 15758410
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20050516
LR  - 20050310
IS  - 1108-7161 (Print)
IS  - 1108-7161 (Linking)
VI  - 2
IP  - 5
DP  - 2002 Sep
TI  - Glutamatergic regulation of bone resorption.
PG  - 423-31
AB  - There has been increasing evidence during the last years that glutamate (Glu), 
      the major neuromediator of the nervous system, contributes to the local 
      regulation of bone cell functions. Several classes of Glu receptors and 
      transporters, as well as molecules involved in glutamate signal transduction in 
      neuronal tissue, were identified in bone. While recent findings suggest that Glu 
      may participate in mechanisms underlying bone formation, several studies indicate 
      that Glu may also control bone resorption. Ionotropic NMDA and metabotropic Glu 
      receptors are expressed by osteoclasts and electrophysiological studies have 
      demonstrated that NMDA receptors (NMDAR) are functional on these cells. In vitro 
      studies have shown that NMDAR are important for osteoclast function since several 
      specific antagonists of NMDAR which block the current induced by Glu in these 
      cells also inhibit bone resorption. Preliminary studies investigating the 
      mechanisms of action of NMDAR antagonists on bone resorption are reviewed in this 
      paper. There is also growing evidence that NMDAR are expressed throughout the 
      osteoclastic differentiation sequence and that antagonists of NMDAR affect 
      osteoclastogenesis. Very few in vivo studies have however investigated the role 
      of Glu in skeletal metabolism and bone resorption and clearly further work is 
      required to demonstrate the relevance of glutamate signaling in the physiology of 
      bone resorption in vivo.
FAU - Chenu, C
AU  - Chenu C
AD  - INSERM Unit 403, Hopital E. Herriot, Lyon, France. chenu@lyon151.inserm.fr
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - J Musculoskelet Neuronal Interact
JT  - Journal of musculoskeletal & neuronal interactions
JID - 101084496
EDAT- 2005/03/11 09:00
MHDA- 2005/03/11 09:01
CRDT- 2005/03/11 09:00
PHST- 2005/03/11 09:00 [pubmed]
PHST- 2005/03/11 09:01 [medline]
PHST- 2005/03/11 09:00 [entrez]
PST - ppublish
SO  - J Musculoskelet Neuronal Interact. 2002 Sep;2(5):423-31.