PMID- 15758417
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20050516
LR  - 20050310
IS  - 1108-7161 (Print)
IS  - 1108-7161 (Linking)
VI  - 2
IP  - 5
DP  - 2002 Sep
TI  - The role of estrogen receptor-beta, in the early age-related bone gain and later 
      age-related bone loss in female mice.
PG  - 479-88
AB  - The molecular and cellular mechanism of estrogen action in skeletal tissue 
      remains unclear. The purpose of this study was to understand the role of estrogen 
      receptor-beta, (ERbeta) on cortical and cancellous bone during growth and aging 
      by comparing the bone phenotype of 6- and 13-month-old female mice with or 
      without ERbeta. Groups of 11-14 wild-type (WT) controls and ERbeta knockout 
      (BERKO) female mice were necropsied at 6 and 13 months of age. At both ages, 
      BERKO mice did not differ significantly from WT controls in uterine weight and 
      uterine epithelial thickness, indicating that ERbeta does not regulate the growth 
      of uterine tissue. Femoral length increased significantly by 5.5% at 6 months of 
      age in BERKO mice compared with WT controls. At 6 months of age, peripheral 
      quantitative computerized tomography (pQCT) analysis of the distal femoral 
      metaphysis (DFM) and femoral shafts showed that BERKO mice had significantly 
      higher cortical bone content and periosteal circumference as compared with WT 
      controls at both sites. In contrast to the findings in cortical bone, at 6 months 
      of age, there was no difference between BERKO and WT mice in trabecular density, 
      trabecular bone volume (TBV), or formation and resorption indices at the DFM. In 
      13-month-old WT mice, TBV (-41%), trabecular density (-27%) and cortical 
      thickness decreased significantly. while marrow cavity and endocortical 
      circumference increased significantly compared with 6-month-old WT mice. These 
      age-related decreases in cancellous and endocortical bone did not occur in BERKO 
      mice. At 13 months of age, BERKO mice had significantly higher total, trabecular 
      and cortical bone, while having significantly lower bone resorption, bone 
      formation and bone turnover in DFM compared with WT mice. These results indicate 
      that deleting ERbeta protected against age-related bone loss in both the 
      cancellous and endocortical compartments by decreasing bone resorption and bone 
      turnover in aged female mice. These data demonstrate that in female mice, ERbeta 
      plays a role in inhibiting periosteal bone formation, longitudinal and radial 
      bone growth during the growth period, while it plays a role in stimulating bone 
      resorption, bone turnover and bone loss on cancellous and endocortical bone 
      surfaces during the aging process.
FAU - Ke, H Z
AU  - Ke HZ
AD  - Department of Cardiovascular Diseases, Groton Laboratories, Connecticut 06340, 
      USA. huazhu_ke@groton.pfizer.com
FAU - Brown, T A
AU  - Brown TA
FAU - Qi, H
AU  - Qi H
FAU - Crawford, D T
AU  - Crawford DT
FAU - Simmons, H A
AU  - Simmons HA
FAU - Petersen, D N
AU  - Petersen DN
FAU - Allen, M R
AU  - Allen MR
FAU - McNeish, J D
AU  - McNeish JD
FAU - Thompson, D D
AU  - Thompson DD
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - J Musculoskelet Neuronal Interact
JT  - Journal of musculoskeletal & neuronal interactions
JID - 101084496
EDAT- 2005/03/11 09:00
MHDA- 2005/03/11 09:01
CRDT- 2005/03/11 09:00
PHST- 2005/03/11 09:00 [pubmed]
PHST- 2005/03/11 09:01 [medline]
PHST- 2005/03/11 09:00 [entrez]
PST - ppublish
SO  - J Musculoskelet Neuronal Interact. 2002 Sep;2(5):479-88.