PMID- 15760381
OWN - NLM
STAT- MEDLINE
DCOM- 20050714
LR  - 20231213
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 53
IP  - 4
DP  - 2005 Apr
TI  - CD83 monocyte-derived dendritic cells are present in human decidua and 
      progesterone induces their differentiation in vitro.
PG  - 199-205
AB  - PROBLEM: Dendritic cells (DCs) play an important role in antigen presentation and 
      immunoregulation. Modifications of the immune response during pregnancy require 
      the participation of DC. The aim of this study was to follow-up the changes of 
      DCs in human decidua and their correlations to progesterone (Pg) concentrations. 
      METHODS OF STUDY: Blood leukocytes were isolated from human decidua and analyzed 
      by flow cytometry for the expression of HLA-DR and CD83 markers. Blood monocytes 
      were cultured to differentiate and mature to DCs in the presence of Pg, estradiol 
      or testosterone and analyzed by flow cytometry. RESULTS: The percentage of mature 
      DCs is increased in human decidua during the 1st trimester. When Pg is added to 
      DCs cultured in vitro the percentage of cells expressing both markers increased 
      in specific and dose-dependent manner. CONCLUSIONS: Pg increases the numbers of 
      monocytic DCs locally and it may be speculated that these cells help the Th1/Th2 
      switching in pregnancy.
FAU - Ivanova, Ekaterina
AU  - Ivanova E
AD  - Laboratory of Molecular Immunology, Bulgarian Academy of Sciences, Sofia, 
      Bulgaria.
FAU - Kyurkchiev, Dobroslav
AU  - Kyurkchiev D
FAU - Altankova, Iskra
AU  - Altankova I
FAU - Dimitrov, Josif
AU  - Dimitrov J
FAU - Binakova, Emilia
AU  - Binakova E
FAU - Kyurkchiev, Stanimir
AU  - Kyurkchiev S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Antigens, CD)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
RN  - 3XMK78S47O (Testosterone)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Antigens, CD
MH  - Cell Differentiation/*drug effects
MH  - Cells, Cultured
MH  - Decidua/*cytology/drug effects/immunology
MH  - Dendritic Cells/*cytology/drug effects/immunology
MH  - Estradiol/pharmacology
MH  - Female
MH  - HLA-DR Antigens/immunology
MH  - Humans
MH  - Immunoglobulins/*immunology
MH  - Membrane Glycoproteins/*immunology
MH  - Monocytes/*cytology/drug effects/immunology
MH  - Pregnancy
MH  - Progesterone/*pharmacology
MH  - Testosterone/pharmacology
MH  - CD83 Antigen
EDAT- 2005/03/12 09:00
MHDA- 2005/07/15 09:00
CRDT- 2005/03/12 09:00
PHST- 2005/03/12 09:00 [pubmed]
PHST- 2005/07/15 09:00 [medline]
PHST- 2005/03/12 09:00 [entrez]
AID - AJI266 [pii]
AID - 10.1111/j.1600-0897.2005.00266.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2005 Apr;53(4):199-205. doi: 
      10.1111/j.1600-0897.2005.00266.x.