PMID- 15761022
OWN - NLM
STAT- MEDLINE
DCOM- 20050801
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 106
IP  - 1
DP  - 2005 Jul 1
TI  - Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in 
      multiple myeloma.
PG  - 353-5
AB  - The t(4;14) translocation detected by fluorescence in situ hybridization (FISH) 
      is an independent prognostic factor for an adverse outcome of multiple myeloma 
      (MM). Because t(4;14) uniquely results in fibroblast growth factor receptor 3 
      (FGFR3) expression, decalcified, paraffin-embedded bone marrow biopsies were 
      immunostained for FGFR3, and its expression was correlated with the t(4;14) 
      status. FISH detected t(4;14) in 16 (19%) of 85 MM patient specimens, and 
      immunocytochemistry detected aberrant FGFR3 expression in 13 (15%). Twelve (75%) 
      t(4;14)-positive cases expressed FGFR3, and 12 (92%) FGFR3-positive cases 
      harbored a t(4;14). FGFR3 expression and t(4;14) were strongly correlated (P < 
      .001). FGFR3 expression by immunohistochemistry was associated with the 
      immunoglobulin A (IgA) isotype (P < .001), a shorter progression-free survival 
      (median, 11.5 versus 25.8 months; P < .001), and a shorter overall survival 
      (median, 19.2 versus 46.3 months; P < .001).
FAU - Chang, Hong
AU  - Chang H
AD  - Department of Laboratory Hematology, Princess Margaret Hospital/University Health 
      Network, McLaughlin Center for Molecular Medicine, University of Toronto, ON, 
      Canada. hong.chang@uhn.on.ca
FAU - Stewart, A Keith
AU  - Stewart AK
FAU - Qi, Xiao Ying
AU  - Qi XY
FAU - Li, Zhi Hua
AU  - Li ZH
FAU - Yi, Qi Long
AU  - Yi QL
FAU - Trudel, Suzanne
AU  - Trudel S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050310
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Receptors, Fibroblast Growth Factor)
RN  - EC 2.7.10.1 (FGFR3 protein, human)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 4
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - *Genetic Testing
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*diagnosis/*genetics
MH  - Predictive Value of Tests
MH  - Protein-Tyrosine Kinases/*genetics
MH  - Receptor, Fibroblast Growth Factor, Type 3
MH  - Receptors, Fibroblast Growth Factor/*genetics
MH  - Translocation, Genetic
EDAT- 2005/03/12 09:00
MHDA- 2005/08/02 09:00
CRDT- 2005/03/12 09:00
PHST- 2005/03/12 09:00 [pubmed]
PHST- 2005/08/02 09:00 [medline]
PHST- 2005/03/12 09:00 [entrez]
AID - S0006-4971(20)53362-4 [pii]
AID - 10.1182/blood-2005-01-0033 [doi]
PST - ppublish
SO  - Blood. 2005 Jul 1;106(1):353-5. doi: 10.1182/blood-2005-01-0033. Epub 2005 Mar 
      10.