PMID- 15761658
OWN - NLM
STAT- MEDLINE
DCOM- 20050705
LR  - 20181201
IS  - 1386-341X (Print)
IS  - 1386-341X (Linking)
VI  - 7
IP  - 2
DP  - 2004
TI  - Isolated familial somatotropinoma.
PG  - 95-101
AB  - The great majority of growth hormone (GH)-secreting pituitary tumors are 
      sporadic, though a few occur with a familial aggregation, either as a component 
      of multiple endocrine neoplasia, type 1 (MEN1) or Carney Complex, or when 
      unassociated with other tumors, as isolated familial somatotropinomas (IFS). This 
      report reviews the clinical and genetic information available from the 46 
      families reported to date with the latter syndrome. In contrast to sporadic 
      tumors, GH-secreting tumors in IFS occur at an earlier age, especially when all 
      affected family members are from a single generation. The IFS gene is believed to 
      be a tumor suppressor gene, based on the presence of loss of heterozygosity. 
      Although the gene still remains to be identified there is strong evidence for 
      linkage to a locus of less than 10 Mb on chromosome 11q13.1-13.3.
FAU - Soares, Beatriz Santana
AU  - Soares BS
AD  - Section of Endocrinology and Metabolism, University of Illinois at Chicago, IL 
      60612, USA.
FAU - Frohman, Lawrence A
AU  - Frohman LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pituitary
JT  - Pituitary
JID - 9814578
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Acromegaly/etiology
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 2
MH  - Family
MH  - Female
MH  - Haplotypes
MH  - Human Growth Hormone/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pituitary Neoplasms/*genetics/metabolism
MH  - Recombination, Genetic
EDAT- 2005/03/12 09:00
MHDA- 2005/07/06 09:00
CRDT- 2005/03/12 09:00
PHST- 2005/03/12 09:00 [pubmed]
PHST- 2005/07/06 09:00 [medline]
PHST- 2005/03/12 09:00 [entrez]
AID - 10.1007/s11102-005-0-04-0 [doi]
PST - ppublish
SO  - Pituitary. 2004;7(2):95-101. doi: 10.1007/s11102-005-0-04-0.