PMID- 15762935
OWN - NLM
STAT- MEDLINE
DCOM- 20050601
LR  - 20191210
IS  - 1398-2273 (Print)
IS  - 1398-2273 (Linking)
VI  - 6
IP  - 4
DP  - 2004 Dec
TI  - Low incidence of infectious complications after nonmyeloablative compared with 
      myeloablative allogeneic stem cell transplantation.
PG  - 171-8
AB  - Allogeneic stem cell transplantation (SCT) using a myeloablative (MA) 
      conditioning regimen is limited to relatively young patients because of increased 
      transplant-related mortality in elderly patients. Nonmyeloablative (NMA) 
      conditioning regimens have been developed aiming to reduce transplant mortality. 
      In this study, we set out to evaluate the post-transplant occurrence of 
      infectious complications in recipients of grafts from human leukocyte antigen 
      (HLA)-identical sibling donors treated with either NMA or MA conditioning 
      regimens. Data of 78 consecutively treated patients were analyzed. An NMA 
      conditioning regimen was used in 40 patients and an MA regimen in 38 patients. A 
      significantly lower rate of episodes of febrile neutropenia (0% vs. 34%, P<0.01) 
      and post-transplant Epstein-Barr virus reactivations (0% vs. 18%, P<0.05) was 
      found in SCT recipients treated with an NMA conditioning regimen compared with an 
      MA conditioning regimen. Furthermore, fewer invasive fungal infections (2% vs. 
      12%, not significant) were diagnosed in the NMA group. The incidence of 
      cytomegalovirus (CMV) reactivations and bacterial infections was low in both 
      groups (CMV reactivations: 13% in both groups; bacterial infections: 10% in the 
      NMA group vs. 8% in the MA group), while CMV disease developed in only 1 patient. 
      Overall, compared to our MA regimen, we found a very low rate of infectious 
      complications after NMA SCT.
FAU - Meijer, E
AU  - Meijer E
AD  - Department of Hematology, University Medical Center, Utrecht, the Netherlands. 
      emeijer@digd.azu.nl
FAU - Dekker, A W
AU  - Dekker AW
FAU - Lokhorst, H M
AU  - Lokhorst HM
FAU - Petersen, E J
AU  - Petersen EJ
FAU - Nieuwenhuis, H K
AU  - Nieuwenhuis HK
FAU - Verdonck, L F
AU  - Verdonck LF
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bacterial Infections/epidemiology
MH  - Cytomegalovirus Infections/epidemiology
MH  - Epstein-Barr Virus Infections/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infections/*epidemiology/etiology
MH  - Male
MH  - Middle Aged
MH  - Mycoses/epidemiology
MH  - Stem Cell Transplantation/*adverse effects/*methods
MH  - Time Factors
EDAT- 2005/03/15 09:00
MHDA- 2005/06/02 09:00
CRDT- 2005/03/15 09:00
PHST- 2005/03/15 09:00 [pubmed]
PHST- 2005/06/02 09:00 [medline]
PHST- 2005/03/15 09:00 [entrez]
AID - TID075 [pii]
AID - 10.1111/j.1399-3062.2004.00075.x [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2004 Dec;6(4):171-8. doi: 10.1111/j.1399-3062.2004.00075.x.