PMID- 15763286
OWN - NLM
STAT- MEDLINE
DCOM- 20060105
LR  - 20050314
IS  - 0165-5876 (Print)
IS  - 0165-5876 (Linking)
VI  - 69
IP  - 4
DP  - 2005 Apr
TI  - Serum ECP and total IgE levels in children with acute laryngotracheobronchitis.
PG  - 493-6
AB  - OBJECTIVE: Eosinophilic cationic protein (ECP) and immunoglobulin E (IgE) are 
      important mediators of allergic inflammation and they are commonly used in the 
      diagnosis and follow-up of allergic diseases. But serum levels of these molecules 
      can also be elevated by some other diseases including viral infections. Acute 
      laryngotracheobronchitis (ALTB) is an important viral infection of upper airway 
      and serum levels of ECP and IgE may increase in patients with ALTB. METHODS: In 
      the present study serum ECP and IgE levels were measured before treatment and on 
      the third day and third week after treatment in 27 patients with ALTB aged 10 
      months to 5 years and were compared with a age matched healthy controls. All 
      patients were treated with nebulized budesonide. RESULTS: We found that 
      pre-treatment ECP levels were significantly higher than post-treatment third days 
      and third weeks (28.3+/-2.3 ng/ml versus 20.2+/-3.2 ng/ml and 11.4+/-1.1 ng/ml, 
      respectively). Similarly, the mean pre-treatment serum IgE values were 
      significantly higher than post-treatment values (131.6+/-17.5 IU/ml versus 
      83.6+/-12.4 IU/ml and 68.2+/-6.7 IU/ml). A positive correlation was found between 
      serum ECP and IgE values for pre-treatment and post-treatment third week values 
      (r=062, p=0.01 and r=0.64, p=0.01, respectively). The pre-treatment serum ECP and 
      IgE levels were significantly higher than those of controls (10.8+/-1.5 ng/ml and 
      43.8+/-6.6 IU/ml, respectively p<0.05). CONCLUSION: In this study it was shown 
      that, serum ECP and IgE levels increase in the acute phase of infection and 
      return to normal after treatment in patients with ALTB such as in allergic 
      patients. This effect of ALTB on serum ECP and total IgE levels should be kept in 
      mind and these parameters should not be used in the diagnosis and follow-up of 
      allergic diseases in children who had had ALTB in recent weeks.
FAU - Cetinkaya, Feyzullah
AU  - Cetinkaya F
AD  - Sisli Etfal Hospital, Department of Pediatrics, 80220 Sisli, Istanbul, Turkey. 
      feyzulkaya@mynet.com
FAU - Cakir, Mahmut
AU  - Cakir M
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20050104
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - 0 (Bronchodilator Agents)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 51333-22-3 (Budesonide)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Bronchodilator Agents/administration & dosage/therapeutic use
MH  - Budesonide/administration & dosage/*therapeutic use
MH  - Child, Preschool
MH  - Croup/blood/*drug therapy
MH  - Eosinophil Cationic Protein/*blood
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Male
MH  - Nebulizers and Vaporizers
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2005/03/15 09:00
MHDA- 2006/01/06 09:00
CRDT- 2005/03/15 09:00
PHST- 2004/07/24 00:00 [received]
PHST- 2004/10/15 00:00 [revised]
PHST- 2004/11/08 00:00 [accepted]
PHST- 2005/03/15 09:00 [pubmed]
PHST- 2006/01/06 09:00 [medline]
PHST- 2005/03/15 09:00 [entrez]
AID - S0165-5876(04)00380-5 [pii]
AID - 10.1016/j.ijporl.2004.11.011 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2005 Apr;69(4):493-6. doi: 
      10.1016/j.ijporl.2004.11.011. Epub 2005 Jan 4.