PMID- 15763626
OWN - NLM
STAT- MEDLINE
DCOM- 20050830
LR  - 20131121
IS  - 0168-3659 (Print)
IS  - 0168-3659 (Linking)
VI  - 103
IP  - 2
DP  - 2005 Mar 21
TI  - The effect of the molecular orientation on the release of antimicrobial 
      substances from uniaxially drawn polymer matrixes.
PG  - 451-64
AB  - A new method of controlled release of low molecular weight biocides incorporated 
      in polymer matrixes is described. The molecular orientation of uniaxially drawn 
      biocide doped polymer films is suggested as a significant parameter for 
      controlled release monitoring. Triclosan, a well-established widespread 
      antibacterial agent, has been incorporated into high density polyethylene (HDPE) 
      films that have been subsequently uniaxially drawn at different draw ratios. The 
      molecular orientation developed was estimated utilizing polarized mu-Raman 
      spectra. Biocide incorporated polymer films, drawn at different draw ratios, have 
      been immersed in ethanol-water solutions (EtOH) and in physiological saline. The 
      release of Triclosan out of the polymer matrix was probed with UV-Vis absorption 
      spectroscopy for a period of time up to 15 months. In all cases, although the 
      film surface of the drawn samples exposed to the liquid solution was higher than 
      the undrawn one, the relevant release rate from the drawn specimens was lower 
      than the non-stretched samples depending on the molecular orientation developed 
      during the drawing process. A note is made of the fact that no significant 
      molecular orientation relaxation of the polyethylene films has been observed even 
      after such a long time of immersion of the drawn films in the liquid solutions.
FAU - Iconomopoulou, S M
AU  - Iconomopoulou SM
AD  - Foundation for Research & Technology-Hellas (FORTH) Institute of Chemical 
      Engineering and High Temperature Chemical Processes (ICE/HT), Odos Stadiou-Rio, 
      P.O. Box 1414, GR-265 04 Rio-Patras, Greece.
FAU - Voyiatzis, G A
AU  - Voyiatzis GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050125
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Solvents)
RN  - 4NM5039Y5X (Triclosan)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Anti-Infective Agents, Local/*chemistry
MH  - Kinetics
MH  - Polyethylene/*chemistry
MH  - Solubility
MH  - Solvents/chemistry
MH  - Spectrum Analysis, Raman
MH  - Triclosan/*chemistry
EDAT- 2005/03/15 09:00
MHDA- 2005/09/01 09:00
CRDT- 2005/03/15 09:00
PHST- 2004/09/21 00:00 [received]
PHST- 2004/12/13 00:00 [revised]
PHST- 2004/12/16 00:00 [accepted]
PHST- 2005/03/15 09:00 [pubmed]
PHST- 2005/09/01 09:00 [medline]
PHST- 2005/03/15 09:00 [entrez]
AID - S0168-3659(04)00636-4 [pii]
AID - 10.1016/j.jconrel.2004.12.014 [doi]
PST - ppublish
SO  - J Control Release. 2005 Mar 21;103(2):451-64. doi: 10.1016/j.jconrel.2004.12.014. 
      Epub 2005 Jan 25.