PMID- 15765807
OWN - NLM
STAT- MEDLINE
DCOM- 20050419
LR  - 20220228
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 10
IP  - 6
DP  - 2004 Dec
TI  - Human T-cell leukemia virus type I Tax induces the expression of dendritic cell 
      markers associated with maturation and activation.
PG  - 358-71
AB  - Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of both adult 
      T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic 
      paraparesis (HAM/TSP). Although the genesis of HAM/TSP likely involves several 
      steps, the generation of a highly specific and effective population of 
      Tax-specific CD8+ cytotoxic T lymphocytes (CTLs) that migrate to the central 
      nervous system (CNS) is of pivotal importance in this neuropathologic process. 
      Presentation of Tax peptides by activated dendritic cells (DCs) to naive CD8+ T 
      cells likely plays an important role in the induction of a Tax-specific CTL 
      response and the eventual neurologic dysfunction observed in HAM/TSP. The immune 
      response mounted during HTLV-I infection is primarily targeted against Tax with 
      both Tax-specific antibodies and CTLs found in HTLV-I-infected individuals, 
      indicating that Tax is available for immune recognition. Studies have suggested 
      that Tax may be secreted from HTLV-I-infected cells and act as an extracellular 
      cytokine, be internalized and processed for presentation, or be transported to 
      the nucleus where it may act as a transcriptional activator. The authors report 
      in this article that purified Tax induces DC activation involving an increase in 
      the production of CD80 and CD86 mRNA in the absence of corresponding protein 
      synthesis. Furthermore, intracellular Tax down-regulates the protein expression 
      of molecules involved in antigen presentation. This implies a difference in the 
      mechanism of Tax activity depending upon its location. Additionally, treatment of 
      JAWS II DCs with extracellular Tax decreases the ability of DCs to present a 
      major histocompatibility complex (MHC) class I-restricted peptide, indicating 
      that Tax likely matures the DCs to the point where presentation of a secondary 
      antigen is restricted. The implication of the experimental results with respect 
      to the generation of a Tax-specific CTL compartment that participates in the 
      genesis of HAM/TSP is discussed.
FAU - Mostoller, Kate
AU  - Mostoller K
AD  - Department of Microbiology and Immunology, The Pennsylvania State University, 
      College of Medicine, Hershey, Pennsylvania, USA
FAU - Norbury, Christopher C
AU  - Norbury CC
FAU - Jain, Pooja
AU  - Jain P
FAU - Wigdahl, Brian
AU  - Wigdahl B
LA  - eng
GR  - AI056094/AI/NIAID NIH HHS/United States
GR  - CA54559/CA/NCI NIH HHS/United States
GR  - NS044801-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Antigens, CD)
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Biomarkers)
RN  - 0 (CD40 Antigens)
RN  - 0 (CD86 protein, human)
RN  - 0 (Gene Products, tax)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens, CD/drug effects/metabolism
MH  - B7-1 Antigen/drug effects/metabolism
MH  - B7-2 Antigen
MH  - Biomarkers
MH  - CD40 Antigens/drug effects/metabolism
MH  - Cell Differentiation/*drug effects/physiology
MH  - Dendritic Cells/*drug effects/metabolism/*virology
MH  - Dose-Response Relationship, Drug
MH  - Flow Cytometry
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - Gene Products, tax/metabolism/*pharmacology
MH  - HTLV-I Infections/*physiopathology
MH  - Histocompatibility Antigens Class I
MH  - Human T-lymphotropic virus 1/metabolism
MH  - Humans
MH  - Membrane Glycoproteins/drug effects/metabolism
MH  - Oligonucleotide Array Sequence Analysis
MH  - RNA, Messenger
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Time Factors
EDAT- 2005/03/16 09:00
MHDA- 2005/04/20 09:00
CRDT- 2005/03/16 09:00
PHST- 2005/03/16 09:00 [pubmed]
PHST- 2005/04/20 09:00 [medline]
PHST- 2005/03/16 09:00 [entrez]
AID - 10.1080/13550280490521104 [doi]
PST - ppublish
SO  - J Neurovirol. 2004 Dec;10(6):358-71. doi: 10.1080/13550280490521104.