PMID- 15765809
OWN - NLM
STAT- MEDLINE
DCOM- 20050419
LR  - 20181113
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 10
IP  - 6
DP  - 2004 Dec
TI  - Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency 
      virus type 1-associated central nervous system disease.
PG  - 383-6
AB  - Interleukin-18 (IL-18) is a proinflammatory cytokine released by macrophages that 
      strongly stimulates the production of interferon-gamma, thereby linking innate 
      and acquired immunity. Its role in human immunodeficiency virus (HIV) 
      pathogenesis is under debate and little is known about its role in neuro-AIDS 
      (acquired immunodeficiency syndrome). Serum and cerebrospinal fluid (CSF) levels 
      of IL-18 were determined by a commercially available enzyme-linked immunosorbent 
      assay (ELISA) in 22 HIV-seropositive patients without neurological symptoms 
      (HIV+), 21 patients with AIDS dementia complex (ADC), and 31 patients with 
      AIDS-defining opportunistic infections (OIs) of the brain. Thirty-two HIV 
      seronegative patients (HIV-) served as controls. Compared to HIV- controls, serum 
      IL-18 levels were increased in HIV+ and ADC but not in OI patients. In contrast, 
      CSF IL-18 levels were elevated in OI patients whereas HIV+ and ADC patients were 
      not different from HIV- controls. We provide evidence for an significantly 
      increased IL-18 level in the CSF of HIV+ patients with cerebral OIs, suggestive 
      of a role for IL-18 in the intrathecal host response to OIs.
FAU - von Giesen, Hans-Jurgen
AU  - von Giesen HJ
AD  - Department of Neurology, Heinrich Heine University, Dusseldorf, Germany. 
      giesenhj@uni-duesseldorf.de
FAU - Jander, Sebastian
AU  - Jander S
FAU - Koller, Hubertus
AU  - Koller H
FAU - Arendt, Gabriele
AU  - Arendt G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Interleukin-18)
SB  - IM
MH  - *AIDS Dementia Complex/blood/cerebrospinal fluid
MH  - *AIDS-Related Opportunistic Infections/blood/cerebrospinal fluid
MH  - *Acquired Immunodeficiency Syndrome/blood/cerebrospinal fluid
MH  - Adult
MH  - *Central Nervous System Infections/blood/cerebrospinal fluid
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HIV-1/immunology
MH  - Humans
MH  - Interleukin-18/*analysis
MH  - Male
MH  - Middle Aged
EDAT- 2005/03/16 09:00
MHDA- 2005/04/20 09:00
CRDT- 2005/03/16 09:00
PHST- 2005/03/16 09:00 [pubmed]
PHST- 2005/04/20 09:00 [medline]
PHST- 2005/03/16 09:00 [entrez]
AID - 10.1080/13550280490523706 [doi]
PST - ppublish
SO  - J Neurovirol. 2004 Dec;10(6):383-6. doi: 10.1080/13550280490523706.