PMID- 15767029
OWN - NLM
STAT- MEDLINE
DCOM- 20050512
LR  - 20081121
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 209
IP  - 2
DP  - 2005 Apr 15
TI  - Innate immunity and hypersensitivity syndrome.
PG  - 161-3
AB  - Viral infections are frequently followed by an increased risk of allergic 
      disorders. We have recently demonstrated an intimate relationship between human 
      herpesvirus 6 (HHV-6) reactivation and drug-induced hypersensitivity syndrome 
      (DIHS). Kano et al. have demonstrated that a dramatic decrease in circulating B 
      and NK cells as well as serum immunoglobulin levels was observed in DIHS at the 
      onset but not in controls. Although these alterations returned to normal on full 
      recovery, NK cells in patients with DIHS displayed a defective ability to express 
      CD122 (IL-2/15R beta) even long after recovery. To test the effect of NK cells, 
      we next investigated NK-depletion experiments. A significant increase in HHV-6 
      DNA was only detected in NK-depleted cultures of PBMC from DIHS patients in the 
      presence of the causative drug. Because gamma delta-T cells play an important 
      role in viral infections, we investigated whether gamma delta-T cells are also 
      important for preventing HHV-6 reactivation. Expansion of gamma delta-T cells was 
      only observed in undepleted cultures of PBMC, not in NK-depleted cultures, from 
      patients in the presence of the causative drug. Thus, cross-talk between NK cells 
      and gamma delta-T cells or B cells would represent a first line of defense 
      against latent virus, such as HHV-6.
FAU - Inaoka, Miyuki
AU  - Inaoka M
AD  - Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Skinkawa, 
      Mitaka, Tokyo 181-8611, Japan. minaoka@rio.odn.ne.jp
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology/physiology
MH  - Drug Hypersensitivity/*immunology
MH  - Herpesvirus 6, Human/immunology
MH  - Humans
MH  - Immunity, Innate/*immunology
MH  - Killer Cells, Natural/immunology/physiology
MH  - Roseolovirus Infections/immunology
MH  - T-Lymphocytes/immunology
MH  - Virus Diseases/complications/immunology
RF  - 161
EDAT- 2005/03/16 09:00
MHDA- 2005/05/13 09:00
CRDT- 2005/03/16 09:00
PHST- 2005/03/16 09:00 [pubmed]
PHST- 2005/05/13 09:00 [medline]
PHST- 2005/03/16 09:00 [entrez]
AID - S0300-483X(04)00710-3 [pii]
AID - 10.1016/j.tox.2004.12.011 [doi]
PST - ppublish
SO  - Toxicology. 2005 Apr 15;209(2):161-3. doi: 10.1016/j.tox.2004.12.011.