PMID- 15767395
OWN - NLM
STAT- MEDLINE
DCOM- 20050426
LR  - 20211203
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 79
IP  - 7
DP  - 2005 Apr
TI  - Retrovirus restriction by TRIM5alpha variants from Old World and New World 
      primates.
PG  - 3930-7
AB  - The TRIM5alpha proteins of humans and some Old World monkeys have been shown to 
      block infection of particular retroviruses following virus entry into the host 
      cell. Infection of most New World monkey cells by the simian immunodeficiency 
      virus of macaques (SIVmac) is restricted at a similar point. Here we examine the 
      antiretroviral activity of TRIM5alpha orthologs from humans, apes, Old World 
      monkeys, and New World monkeys. Chimpanzee and orangutan TRIM5alpha proteins 
      functionally resembled human TRIM5alpha, potently restricting infection by 
      N-tropic murine leukemia virus (N-MLV) and moderately restricting human 
      immunodeficiency virus type 1 (HIV-1) infection. Notably, TRIM5alpha proteins 
      from several New World monkey species restricted infection by SIVmac and the SIV 
      of African green monkeys, SIVagm. Spider monkey TRIM5alpha, which has an expanded 
      B30.2 domain v3 region due to a tandem triplication, potently blocked infection 
      by a range of retroviruses, including SIVmac, SIVagm, HIV-1, and N-MLV. Tandem 
      duplications in the TRIM5alpha B30.2 domain v1 region of African green monkeys 
      are also associated with broader antiretroviral activity. Thus, variation in 
      TRIM5alpha proteins among primate species accounts for the observed patterns of 
      postentry restrictions in cells from these animals. The TRIM5alpha proteins of 
      some monkey species exhibit dramatic lengthening of particular B30.2 variable 
      regions and an expanded range of susceptible retroviruses.
FAU - Song, Byeongwoon
AU  - Song B
AD  - Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division 
      of AIDS, Harvard Medical School, Boston, MA, USA.
FAU - Javanbakht, Hassan
AU  - Javanbakht H
FAU - Perron, Michel
AU  - Perron M
FAU - Park, Do Hyun
AU  - Park DH
FAU - Stremlau, Matthew
AU  - Stremlau M
FAU - Sodroski, Joseph
AU  - Sodroski J
LA  - eng
SI  - GENBANK/AY740612
SI  - GENBANK/AY740613
SI  - GENBANK/AY740614
SI  - GENBANK/AY740615
SI  - GENBANK/AY740616
SI  - GENBANK/AY740617
SI  - GENBANK/AY740618
GR  - P030 AI28691/AI/NIAID NIH HHS/United States
GR  - R01 AI063987/AI/NIAID NIH HHS/United States
GR  - P30 AI028691/AI/NIAID NIH HHS/United States
GR  - HL54785/HL/NHLBI NIH HHS/United States
GR  - P50 HL054785/HL/NHLBI NIH HHS/United States
GR  - AI063987/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Anti-Retroviral Agents)
RN  - 0 (Antiviral Restriction Factors)
RN  - 0 (Carrier Proteins)
RN  - 0 (Proteins)
RN  - 0 (Tripartite Motif Proteins)
RN  - EC 2.3.2.27 (TRIM5 protein, human)
RN  - EC 2.3.2.27 (TRIM5(alpha) protein, rhesus monkey)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Anti-Retroviral Agents
MH  - Antiviral Restriction Factors
MH  - Carrier Proteins/chemistry/genetics/*physiology
MH  - Cebidae
MH  - Cells, Cultured
MH  - Cercopithecidae
MH  - HIV-1/growth & development
MH  - Leukemia Virus, Murine/growth & development
MH  - Molecular Sequence Data
MH  - Proteins/chemistry/genetics/*physiology
MH  - Retroviridae/*growth & development
MH  - Sequence Analysis, DNA
MH  - Simian Immunodeficiency Virus/growth & development
MH  - Tripartite Motif Proteins
MH  - Ubiquitin-Protein Ligases
PMC - PMC1061569
EDAT- 2005/03/16 09:00
MHDA- 2005/04/27 09:00
PMCR- 2005/04/01
CRDT- 2005/03/16 09:00
PHST- 2005/03/16 09:00 [pubmed]
PHST- 2005/04/27 09:00 [medline]
PHST- 2005/03/16 09:00 [entrez]
PHST- 2005/04/01 00:00 [pmc-release]
AID - 79/7/3930 [pii]
AID - 2162-04 [pii]
AID - 10.1128/JVI.79.7.3930-3937.2005 [doi]
PST - ppublish
SO  - J Virol. 2005 Apr;79(7):3930-7. doi: 10.1128/JVI.79.7.3930-3937.2005.