PMID- 15771793
OWN - NLM
STAT- MEDLINE
DCOM- 20051014
LR  - 20061115
IS  - 0253-3766 (Print)
IS  - 0253-3766 (Linking)
VI  - 27
IP  - 1
DP  - 2005 Jan
TI  - [A comparative study of E-cadherin mRNA expression in primary tumors and 
      metastatic foci of gastric cancer].
PG  - 25-8
AB  - OBJECTIVE: To evaluate the expression level of E-cadherin (E-CD) mRNA in gastric 
      cancer and its relation to biological behavior. METHODS: The expression level of 
      E-CD mRNA was examined by RT-PCR in primary tumors, nearby tumor free tissues, 
      metastatic lymph nodes and peritoneal lavage fluid from 35 cases with advanced 
      gastric cancer. RESULTS: All the specimens expressed E-CD mRNA. The expression 
      level in primary tumors was significantly decreased compared with that in nearby 
      tumor free tissues (P < 0.01). The decrease in E-CD expression was more marked in 
      poorly differentiated, diffusely growing tumors invading through serosal 
      membrane. E-CD expression in the primary tumor was more significantly decreased 
      with the increase in the number of lymph nodes (LNS) metastasized and progression 
      of the clinical stage. However, E-CD expression level was significantly increased 
      in metastatic LNs. The difference in E-CD mRNA level between metastatic LN and 
      the primary tumor was increasing with progression of the disease. The expression 
      level of E-CD mRNA in peritoneal lavage fluid was increased in patients whose 
      tumor had penetrated through serosa and larvage fluid was positive on exfoliative 
      cytologic examination. CONCLUSION: E-CD mRNA expression in primary tumors of 
      gastric cancer is negatively correlated with the malignant behavior of the tumor. 
      Nonetheless, that in the metastatic lymph nodes is increased with the progression 
      of the disease.
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Surgical Oncology, First Affiliated Hospital of China Medical 
      University, Shenyang 110001, China.
FAU - Dai, Dong-Qiu
AU  - Dai DQ
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Zhong Liu Za Zhi
JT  - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JID - 7910681
RN  - 0 (Cadherins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Ascitic Fluid/*metabolism
MH  - Cadherins/*biosynthesis/genetics
MH  - Female
MH  - Humans
MH  - Lymph Nodes/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Stomach Neoplasms/*metabolism/pathology
EDAT- 2005/03/18 09:00
MHDA- 2005/10/15 09:00
CRDT- 2005/03/18 09:00
PHST- 2005/03/18 09:00 [pubmed]
PHST- 2005/10/15 09:00 [medline]
PHST- 2005/03/18 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Zhong Liu Za Zhi. 2005 Jan;27(1):25-8.