PMID- 15772970
OWN - NLM
STAT- MEDLINE
DCOM- 20050603
LR  - 20071115
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 31
IP  - 5
DP  - 2005 May
TI  - Beta-chemokine receptor expression in idiopathic inflammatory myopathies.
PG  - 621-7
AB  - Beta-chemokines attract and activate T cells and monocytes and have a key role in 
      chronic inflammation. Certain beta-chemokines, such as monocyte chemoattractant 
      protein-1 (MCP-1), have been reported to be upregulated in the idiopathic 
      inflammatory myopathies (IIM). We studied the distribution of beta-chemokine 
      receptors in polymyositis (PM), sporadic inclusion-body myositis (sIBM), 
      dermatomyositis (DM), and control samples. CCR1-5 were localized to blood vessels 
      in all samples. In addition, increased endothelial expression of CCR2A was 
      observed in IIM. Subsets of inflammatory cells, identified as macrophages and T 
      cells, in all three types of IIM expressed CCR2A, CCR2B, CCR3, CCR4, and CCR5. In 
      contrast to an earlier report, we found CCR2B to be the most prominent MCP-1 
      receptor on inflammatory cells in IIM, especially in PM and sIBM. Strong CCR4 
      expression was present on myonuclei of regenerating muscle fibers. The prominence 
      of the CCR2 receptors further underlines the importance of the interaction with 
      their ligand MCP-1 in the immunopathogenesis of IIM and puts CCR2B forward as a 
      potential target for future therapeutic intervention.
FAU - De Paepe, Boel
AU  - De Paepe B
AD  - Department of Neurology, Neuromuscular Laboratory, Ghent University Hospital, De 
      Pintelaan 185, B-9000 Ghent, Belgium.
FAU - De Bleecker, Jan L
AU  - De Bleecker JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (CCR4 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, CCR4)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Blood Vessels/*immunology/pathology
MH  - Blotting, Western
MH  - Chemokine CCL2/metabolism
MH  - Chemotaxis, Leukocyte/immunology
MH  - Endothelial Cells/immunology/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Macrophages/immunology
MH  - Muscle, Skeletal/blood supply/*immunology/*pathology
MH  - Myositis/*immunology/*pathology
MH  - Receptors, CCR2
MH  - Receptors, CCR4
MH  - Receptors, Chemokine/*biosynthesis/immunology/metabolism
MH  - T-Lymphocytes/immunology
EDAT- 2005/03/18 09:00
MHDA- 2005/06/04 09:00
CRDT- 2005/03/18 09:00
PHST- 2005/03/18 09:00 [pubmed]
PHST- 2005/06/04 09:00 [medline]
PHST- 2005/03/18 09:00 [entrez]
AID - 10.1002/mus.20294 [doi]
PST - ppublish
SO  - Muscle Nerve. 2005 May;31(5):621-7. doi: 10.1002/mus.20294.