PMID- 15773538
OWN - NLM
STAT- MEDLINE
DCOM- 20050628
LR  - 20130912
IS  - 0011-4162 (Print)
IS  - 0011-4162 (Linking)
VI  - 75
IP  - 2 Suppl
DP  - 2005 Feb
TI  - The mechanism of action of topical retinoids.
PG  - 10-3; discussion 13
AB  - UV irradiation of human skin sets in motion a complex sequence of events that 
      causes damage to the dermal matrix. When topical tretinoin is applied to human 
      skin, any collagen deficiency existing in photoaged skin is remedied at least 
      partially, and the skin is primed to prevent further matrix degradation induced 
      by solar UV. Retinoids, therefore, have become essential in the treatment and 
      prevention of photoaging. This article describes the mechanism of action of 
      retinoids, including how they are mediated through retinoic acid receptors (RARs) 
      and retinoid X receptors (RXRs), how they block inflammation mediators, and how 
      production of procollagen is increased to augment the formation of types I and 
      III collagen. Three naturally occurring retinoids are reviewed.
FAU - Kang, Sewon
AU  - Kang S
AD  - University of Michigan Medical Center, Ann Arbor, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cutis
JT  - Cutis
JID - 0006440
RN  - 0 (Procollagen)
RN  - 0 (RNA, Messenger)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
SB  - IM
MH  - Acne Vulgaris/*drug therapy/pathology
MH  - Administration, Topical
MH  - Female
MH  - Humans
MH  - Male
MH  - Procollagen/biosynthesis/*drug effects
MH  - RNA, Messenger/analysis
MH  - Retinoid X Receptors/*drug effects
MH  - Retinoids/pharmacology/*therapeutic use
MH  - Sensitivity and Specificity
MH  - Skin Aging/drug effects/*pathology
RF  - 5
EDAT- 2005/03/19 09:00
MHDA- 2005/06/29 09:00
CRDT- 2005/03/19 09:00
PHST- 2005/03/19 09:00 [pubmed]
PHST- 2005/06/29 09:00 [medline]
PHST- 2005/03/19 09:00 [entrez]
PST - ppublish
SO  - Cutis. 2005 Feb;75(2 Suppl):10-3; discussion 13.