PMID- 15773966
OWN - NLM
STAT- MEDLINE
DCOM- 20050620
LR  - 20050318
IS  - 0934-0874 (Print)
IS  - 0934-0874 (Linking)
VI  - 18
IP  - 4
DP  - 2005 Apr
TI  - Long-term follow-up of double kidney transplantation using a score for evaluation 
      of marginal donors*.
PG  - 453-7
AB  - To face the problem of organ shortage, marginal grafts from 36 donors which had 
      been refused for single transplantation were used for double-kidney 
      transplantation (D-KTX). The residual kidney function was evaluated by the 
      Muenster double kidney score. In a 5-year period kidneys from 57 marginal donors 
      were transferred to our center. According to the Muenster double kidney score, 
      the kidneys were distributed to single, double or refusal of transplantation. 
      Sixteen male and 20 female donors were used for D-KTX (70+/-9.3 years, range 
      53-86). Thirty-six recipients (23 male, 13 female; 60.5+/-6.9 years) were 
      double-grafted within a mean cold ischemic time of 19.3+/-3.4 h. 
      Immunosuppression varied according to human leukocyte antigen (HLA)-mismatch. 
      Graft and patient survival was observed up to 5 years. Initial graft function 
      rate was 69%. Two recipients had a primary nonfunction (5.5%) and nine recipients 
      suffered from delayed graft function (DGF; 25%). One-, 2-, 3-year creatinine 
      values were 1.6 +/- 0.5, 1.9 +/- 0.6 and 2.2 +/- 0.7 mg/dl, respectively. One-, 
      2-, 3-, 4- and 5-year function rate was 93.7%, 93.5%, 81.8%, 76.4% and 55%, 
      respectively (n = 32, 31, 22, 17 and 9). Acute rejection rate was 19%. 4 grafts 
      were lost to chronic rejection (months 22, 25, 28, 48). Six (16%) died in 
      long-term follow-up because of pneumonia (n = 2), carcinoma of the lung (n = 1), 
      cardial complications (n = 2) and multiorgan failure (n = 1). D-KTX is a safe way 
      to face the problem of organ shortage. However, a score for preoperative 
      evaluation of marginal kidneys for single, dual or refusal of transplantation is 
      essential.
FAU - Wolters, Heiner H
AU  - Wolters HH
AD  - Department of General Surgery, Muenster University Hospital, Germany. 
      wolterh@uni-muenster.de
FAU - Palmes, Daniel
AU  - Palmes D
FAU - Heidenreich, Stefan
AU  - Heidenreich S
FAU - August, Christian
AU  - August C
FAU - Brockmann, Jens
AU  - Brockmann J
FAU - Senninger, Norbert
AU  - Senninger N
FAU - Dietl, Karl-Heinz
AU  - Dietl KH
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Aged, 80 and over
MH  - *Donor Selection
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/epidemiology
MH  - Graft Survival
MH  - Humans
MH  - Incidence
MH  - Kidney/physiopathology
MH  - Kidney Transplantation/*methods
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Survival Analysis
MH  - *Tissue Donors
EDAT- 2005/03/19 09:00
MHDA- 2005/06/21 09:00
CRDT- 2005/03/19 09:00
PHST- 2005/03/19 09:00 [pubmed]
PHST- 2005/06/21 09:00 [medline]
PHST- 2005/03/19 09:00 [entrez]
AID - TRI068 [pii]
AID - 10.1111/j.1432-2277.2004.00068.x [doi]
PST - ppublish
SO  - Transpl Int. 2005 Apr;18(4):453-7. doi: 10.1111/j.1432-2277.2004.00068.x.