PMID- 15778019
OWN - NLM
STAT- MEDLINE
DCOM- 20050425
LR  - 20220330
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 43
IP  - 5
DP  - 2005 May
TI  - Toxicology and safety of anti-oxidant of bamboo leaves. Part 1: Acute and 
      subchronic toxicity studies on anti-oxidant of bamboo leaves.
PG  - 783-92
AB  - The anti-oxidant of bamboo leaves (AOB) has recently been certificated as a novel 
      kind of natural anti-oxidant by the Ministry of Health of the People's Republic 
      of China, and has been used in various food systems. Here, AOB was subjected to a 
      series of acute and subchronic toxicological tests to evaluate its safety. It was 
      examined to evaluate acute oral toxicity by using Kun-Ming mice and 
      Sprague-Dawley rats, and its mutagenic potential assessed by reverse mutation 
      test using Salmonella typhimurium, bone marrow cell micronucleus test using 
      Kun-Ming mice, and sperm abnormality test using Kun-Ming mice. In addition, a 
      90-day oral toxicity study using Sprague-Dawley rats was conducted to evaluate 
      subchronic toxicology. The results showed that the maximum tolerated dose (MTD) 
      of AOB was >10 g/kg body weight in both rats and in mice, which can be regarded 
      as virtually non-toxic. No mutagenicity evidence was detected in any of the three 
      mutagenic tests. Administration at levels of 1.43, 2.87 and 4.30 g/kg per day to 
      the rats for 90 days did not induce significant hematological, clinic, chemical 
      and histopathological changes, and suggested a no-observed-adverse-effect level 
      (NOAEL) of 4.30 g/kg per day. These results indicate that AOB can be generally 
      regarded as safe for use as a food additive.
FAU - Lu, Baiyi
AU  - Lu B
AD  - Department of Food Science and Nutrition, College of Biosystems Engineering and 
      Food Science, Zhejiang University, Hangzhou 310029, Zhejiang Province, PR China.
FAU - Wu, Xiaoqin
AU  - Wu X
FAU - Tie, Xiaowei
AU  - Tie X
FAU - Zhang, Yu
AU  - Zhang Y
FAU - Zhang, Ying
AU  - Zhang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Antioxidants)
RN  - 0 (Food Additives)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antioxidants/*toxicity
MH  - Blood Chemical Analysis
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Food Additives/*toxicity
MH  - Male
MH  - Maximum Tolerated Dose
MH  - Mice
MH  - Micronucleus Tests
MH  - Mutagenicity Tests
MH  - No-Observed-Adverse-Effect Level
MH  - Plant Leaves/*toxicity
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Safety
MH  - Sasa/*chemistry
MH  - Spermatozoa/drug effects
MH  - Toxicity Tests, Acute
MH  - Toxicity Tests, Chronic
EDAT- 2005/03/22 09:00
MHDA- 2005/04/26 09:00
CRDT- 2005/03/22 09:00
PHST- 2004/09/08 00:00 [received]
PHST- 2005/01/26 00:00 [revised]
PHST- 2005/01/26 00:00 [accepted]
PHST- 2005/03/22 09:00 [pubmed]
PHST- 2005/04/26 09:00 [medline]
PHST- 2005/03/22 09:00 [entrez]
AID - S0278-6915(05)00051-7 [pii]
AID - 10.1016/j.fct.2005.01.019 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2005 May;43(5):783-92. doi: 10.1016/j.fct.2005.01.019.