PMID- 15778054
OWN - NLM
STAT- MEDLINE
DCOM- 20050728
LR  - 20131121
IS  - 0378-5173 (Print)
IS  - 0378-5173 (Linking)
VI  - 293
IP  - 1-2
DP  - 2005 Apr 11
TI  - Preparation of molecularly imprinted cyclodextrin microspheres.
PG  - 165-70
AB  - Molecularly imprinted cyclodextrins (MI-CDs) are prepared by cross-linking CDs in 
      the presence of a template molecule. The binding ability of MI-CDs to the 
      template molecule is specific; therefore, MI-CDs will prove to be useful 
      materials. In this study, we prepared microspheres of MI-CDs (MSs-MI-CD) in a 
      dimethylsulfoxide/poly(dimethylsiloxane) (PDMS) emulsion, using cholesterol as 
      the template molecule. MSs-MI-CD were prepared under various conditions and were 
      evaluated with respect to their morphology, size, and binding ability. MSs-MI-CD 
      prepared at 65 degrees C were in an aggregated form; however, we could prepare 
      separated and uniform MSs-MI-CD at 95 degrees C. The viscosity of PDMS influenced 
      the size of MSs-MI-CD. The mean particle diameters of MSs-MI-CD prepared with 50 
      and 1000 mm(2)/s PDMS were 146 and 43 microm, respectively. The binding ability 
      of MSs-MI-CD to cholesterol was higher than that of non-imprinted microspheres. 
      Cholesterol imprinting also promoted the binding ability to other steroids; 
      however, the increase in binding ability was most remarkable in the case of 
      cholesterol, suggesting that we successfully introduced the cholesterol-specific 
      binding ability into MSs-MI-CD. The novel MSs-MI-CD preparation method is useful 
      and simple, and it will provide opportunities for further studies on the specific 
      binding ability of MI-CDs.
FAU - Egawa, Y
AU  - Egawa Y
AD  - Pharmaceutical Research Laboratories, Nikken Chemicals Co. Ltd., 1-346 
      Kitabukuro-cho, Ohmiya-ku, Saitama-shi, Saitama, Japan. moguinukuma@yahoo.co.jp
FAU - Shimura, Y
AU  - Shimura Y
FAU - Nowatari, Y
AU  - Nowatari Y
FAU - Aiba, D
AU  - Aiba D
FAU - Juni, K
AU  - Juni K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Cyclodextrins)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Cholesterol/metabolism
MH  - Cyclodextrins/*chemical synthesis/metabolism
MH  - *Microspheres
EDAT- 2005/03/22 09:00
MHDA- 2005/07/29 09:00
CRDT- 2005/03/22 09:00
PHST- 2004/11/21 00:00 [received]
PHST- 2004/12/25 00:00 [revised]
PHST- 2004/12/26 00:00 [accepted]
PHST- 2005/03/22 09:00 [pubmed]
PHST- 2005/07/29 09:00 [medline]
PHST- 2005/03/22 09:00 [entrez]
AID - S0378-5173(05)00055-4 [pii]
AID - 10.1016/j.ijpharm.2004.12.020 [doi]
PST - ppublish
SO  - Int J Pharm. 2005 Apr 11;293(1-2):165-70. doi: 10.1016/j.ijpharm.2004.12.020.