PMID- 15778508
OWN - NLM
STAT- MEDLINE
DCOM- 20080227
LR  - 20191210
IS  - 0257-277X (Print)
IS  - 0257-277X (Linking)
VI  - 31
IP  - 2
DP  - 2005
TI  - Understanding sex biases in immunity: effects of estrogen on the differentiation 
      and function of antigen-presenting cells.
PG  - 91-106
AB  - The initiation and perpetuation of innate and adaptive immunity is dependent on 
      the ability of professional antigen-presenting cells (APCs) to sense inflammatory 
      stimuli; produce cytokines; and internalize, degrade, and present antigens via 
      surface major histocompatibility complex (MHC) molecules. Dendritic cells (DCs), 
      macrophages, and B lymphocytes express estrogen receptors, indicating that the 
      steroid sex hormone estrogen might directly modulate the function of these cells 
      during immune responses. Sex-specific parameters of immune function have been 
      identified during autoimmunity and the pathogenesis of infectious disease, which 
      show sex biases in their incidence and manifestation; female immunity also varies 
      as estrogen levels change. In this article, we summarize studies that demonstrate 
      effects of estrogen on the differentiation or function of APCs in model in vitro 
      systems, or under circumstances of natural or imposed variation in estrogen 
      levels in vivo.
FAU - Nalbandian, Greg
AU  - Nalbandian G
AD  - Division of Immunology, Beckman Research Institute, City of Hope National Medical 
      Center, CA 91010, USA.
FAU - Kovats, Susan
AU  - Kovats S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Antigen-Presenting Cells/cytology/*immunology/*metabolism
MH  - Cell Differentiation/*immunology
MH  - Estrogens/*physiology
MH  - Female
MH  - Humans
MH  - Immunity, Innate/*immunology
MH  - Infections/*immunology/*physiopathology
MH  - Male
MH  - Receptors, Estrogen/physiology
MH  - *Sex Characteristics
RF  - 131
EDAT- 2005/03/22 09:00
MHDA- 2008/02/28 09:00
CRDT- 2005/03/22 09:00
PHST- 2005/03/22 09:00 [pubmed]
PHST- 2008/02/28 09:00 [medline]
PHST- 2005/03/22 09:00 [entrez]
AID - IR:31:2:091 [pii]
AID - 10.1385/IR:31:2:091 [doi]
PST - ppublish
SO  - Immunol Res. 2005;31(2):91-106. doi: 10.1385/IR:31:2:091.