PMID- 15778844
OWN - NLM
STAT- MEDLINE
DCOM- 20050628
LR  - 20181201
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 446
IP  - 4
DP  - 2005 Apr
TI  - Inflammatory myofibroblastic tumor of the posterior mediastinum: an older adult 
      case with anaplastic lymphoma kinase abnormalities determined using 
      immunohistochemistry and fluorescence in situ hybridization.
PG  - 451-5
AB  - Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm that usually occurs 
      in children and young adults. Anaplastic lymphoma kinase (ALK) abnormalities in 
      IMT, determined using immunohistochemistry and/or molecular genetic studies, 
      including fluorescence in situ hybridization (FISH), have almost been limited to 
      children and young adults. In elderly cases of IMT, these ALK abnormalities are 
      very rare. We report on a case of IMT arising in the posterior mediastinum of a 
      59-year-old Japanese man that showed ALK abnormalities determined using 
      immunohistochemistry and FISH, suggesting the neoplastic nature of a subset of 
      IMTs in older patients similar to those in younger ones and the presence of an 
      additional mechanism(s) that allows them to start to grow late.
FAU - Makimoto, Yoshifumi
AU  - Makimoto Y
AD  - Department of Pathology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, 814-0180, Fukuoka , Japan.
FAU - Nabeshima, Kazuki
AU  - Nabeshima K
FAU - Iwasaki, Hiroshi
AU  - Iwasaki H
FAU - Ishiguro, Akiko
AU  - Ishiguro A
FAU - Miyoshi, Tatsu
AU  - Miyoshi T
FAU - Shiraishi, Takeshi
AU  - Shiraishi T
FAU - Iwasaki, Akinori
AU  - Iwasaki A
FAU - Shirakusa, Takayuki
AU  - Shirakusa T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20050319
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Anaplastic Lymphoma Kinase
MH  - Biomarkers, Tumor/metabolism
MH  - Diagnosis, Differential
MH  - Fibroblasts/enzymology/pathology
MH  - Fibroma/diagnosis
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mediastinal Neoplasms/enzymology/genetics/*pathology/surgery
MH  - Middle Aged
MH  - Neoplasms, Muscle Tissue/enzymology/genetics/*pathology/surgery
MH  - Neurofibrosarcoma/diagnosis
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - Radiography, Thoracic
MH  - Receptor Protein-Tyrosine Kinases
MH  - Treatment Outcome
EDAT- 2005/03/22 09:00
MHDA- 2005/06/29 09:00
CRDT- 2005/03/22 09:00
PHST- 2004/08/23 00:00 [received]
PHST- 2004/10/30 00:00 [accepted]
PHST- 2005/03/22 09:00 [pubmed]
PHST- 2005/06/29 09:00 [medline]
PHST- 2005/03/22 09:00 [entrez]
AID - 10.1007/s00428-004-1170-6 [doi]
PST - ppublish
SO  - Virchows Arch. 2005 Apr;446(4):451-5. doi: 10.1007/s00428-004-1170-6. Epub 2005 
      Mar 19.