PMID- 15779490
OWN - NLM
STAT- MEDLINE
DCOM- 20050422
LR  - 20190117
IS  - 1726-4901 (Print)
IS  - 1726-4901 (Linking)
VI  - 67
IP  - 12
DP  - 2004 Dec
TI  - Subarachnoid hemorrhage and death following coingestion of MDMA with other drugs.
PG  - 640-3
AB  - Ecstasy, the popular name for 3,4-methylenedioxymethamphetamine (MDMA), is a 
      synthetic amphetamine derivative. It stimulates the sympathetic nervous system, 
      producing serious adverse effects on the cardiovascular system. We present a 
      20-year-old female patient, who developed subarachnoid hemorrhage (SAH) and death 
      following MDMA and coingestion with other drugs. She suffered from severe 
      headache followed by vomiting, and conscious change 5 hours after an intake of 1 
      tablet MDMA and other drugs at a dance club. Her blood pressure was 226/164 mmHg, 
      pulse rate 164/min, respiratory rate 30/min on arrival at our emergency 
      department. Diffuse rales were heard over both lung fields. Both pupils' sizes 
      were 4 mm, with sluggish reaction to light. A 12 lead electrocardiograph showed 
      sinus tachycardia, ST depression in the inferior leads and V4 to V6 precordial 
      leads. Laboratory findings revealed normal except a slightly raised white cell 
      count and glucose. Arterial blood gas analysis showed pH was 7.333, with PaCO2 
      24.6 mmHg, PaO2 151.7 mmHg and HCO3 12.8 mmol/L. Chest x-ray revealed acute 
      pulmonary edema. Urgent computerized tomography scanning of the head demonstrated 
      SAH. Her condition continued to deteriorate, and went to deep coma and shock 
      status. She expired on the second day although we treated aggressively.
FAU - Ho, Min-Po
AU  - Ho MP
AD  - Department of Emergency Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan, 
      ROC. hominpo@yahoo.com.tw
FAU - Tsai, Jen-Lieu
AU  - Tsai JL
FAU - Wong, Yin-Kin
AU  - Wong YK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Common Cold/drug therapy
MH  - Death
MH  - Female
MH  - Hallucinogens/*adverse effects
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Pulmonary Edema/*chemically induced/diagnostic imaging
MH  - Radiography
MH  - Subarachnoid Hemorrhage/*chemically induced
MH  - *Substance-Related Disorders
MH  - Urinary Tract Infections/drug therapy
EDAT- 2005/03/23 09:00
MHDA- 2005/04/23 09:00
CRDT- 2005/03/23 09:00
PHST- 2005/03/23 09:00 [pubmed]
PHST- 2005/04/23 09:00 [medline]
PHST- 2005/03/23 09:00 [entrez]
PST - ppublish
SO  - J Chin Med Assoc. 2004 Dec;67(12):640-3.