PMID- 15779847
OWN - NLM
STAT- MEDLINE
DCOM- 20050510
LR  - 20170511
IS  - 0001-5385 (Print)
IS  - 0001-5385 (Linking)
VI  - 60
IP  - 1
DP  - 2005 Feb
TI  - Intracardiac basic fibroblast growth factor and transforming growth factor-beta 1 
      mRNA and their proteins expression level in patients with pressure or 
      volume-overload right or left ventricular hypertrophy.
PG  - 21-5
AB  - OBJECTIVES: The aim of the study was to investigate the pathogenic role of 
      intracardiac basic fibroblast growth factor (bFGF) and transforming growth factor 
      beta-1 (TGF beta-1) mRNA and their protein expression level in patients with 
      ventricular volume or pressure-overload. BACKGROUND: Myocardial hypertrophy is 
      responsiveness of cardiomyocytes and interstitial cells to ventricular stress 
      produced by ventricular preload or/and afterload and a series of growth factors. 
      However, the molecular mechanism by which the changes of bFGF and TGF beta-1 mRNA 
      and their protein expression level in patients with volume or pressure-overload 
      lead to distinct forms of cardiac hypertrophy is unclear. METHODS: 32 patients 
      were divided into two groups: 16 patients with cardiac volume overload leading to 
      left ventricular hypertrophy (VG) and 16 patients with pressure overload leading 
      to right ventricular hypertrophy (PG), respectively, as compared with 5 
      unexpected deaths of noncardiac disease (CG), which is determinated by 
      echocardiography and/or pathologic examination following operation; intracardiac 
      bFGF and TGF beta-1 mRNA and their protein expression level were determined by 
      immunohistochemistry and in situ hybridization as well as image analysis; 
      cardiomyocytes and fibril collagen of type I and III were examined by 
      haemotoxylin and eosin (HE) staining or sirius-red staining. RESULTS: Cardiocyte 
      transverse diameter and fibril collagen of extracellular matrix, intracardiac 
      bFGF and TGF beta-1 mRNA and their protein expression level in patients with 
      volume or pressure-overload were significantly increased in both VG and PG, as 
      compared with CG. CONCLUSION: This is the first paper to suggest that 
      intracardiac bFGF and TGF beta-1 play a pivotal role in patients with pressure or 
      volume-overload leading to right or left ventricular hypertrophy, composed of 
      cardiomyocyte hypertrophy and extracellular matrix proliferation.
FAU - He, Zuo Yun
AU  - He ZY
AD  - Department of Cardiology, Xinqiao Hospital, Third Military Medical University, 
      Chongqing 400037, China. yslhzy@yahoo.com.cn
FAU - Feng, Bing
AU  - Feng B
FAU - Yang, Sheng Li
AU  - Yang SL
FAU - Luo, Hui Lan
AU  - Luo HL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Messenger)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/analysis
MH  - Biopsy, Needle
MH  - Blood Chemical Analysis
MH  - Child
MH  - Cohort Studies
MH  - Echocardiography, Doppler
MH  - Female
MH  - Fibroblast Growth Factor 2/analysis/*metabolism
MH  - Heart Function Tests
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*metabolism/*physiopathology
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Prognosis
MH  - RNA, Messenger/analysis
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Transforming Growth Factor beta/analysis/*metabolism
MH  - Transforming Growth Factor beta1
MH  - Ventricular Pressure/*physiology
EDAT- 2005/03/23 09:00
MHDA- 2005/05/11 09:00
CRDT- 2005/03/23 09:00
PHST- 2005/03/23 09:00 [pubmed]
PHST- 2005/05/11 09:00 [medline]
PHST- 2005/03/23 09:00 [entrez]
AID - 10.2143/AC.60.1.2005044 [doi]
PST - ppublish
SO  - Acta Cardiol. 2005 Feb;60(1):21-5. doi: 10.2143/AC.60.1.2005044.