PMID- 15780643
OWN - NLM
STAT- MEDLINE
DCOM- 20050705
LR  - 20161124
IS  - 1063-4584 (Print)
IS  - 1063-4584 (Linking)
VI  - 13
IP  - 4
DP  - 2005 Apr
TI  - Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds.
PG  - 297-309
AB  - OBJECTIVE: The natural repair of osteochondral defects can be enhanced with 
      biocompatible, biodegradable materials that support the repair process. It is our 
      hypothesis that hyaluronan-based scaffolds are superior to synthetic scaffolds 
      because they provide biological cues. We tested this thesis by comparing two 
      hyaluronan-based scaffolds [auto cross-linked polysaccharide polymer (ACP) and 
      HYAFF-11] to polyester-based scaffolds [poly(DL-lactic-co-glycolic acid) (PLGA) 
      and poly(L-lactic acid) (PLLA)] with similar pore size, porosity and degradation 
      times. DESIGN: Fifty-four rabbits received bilateral osteochondral defects. One 
      defect received a hyaluronan-based scaffold and the contralateral defect received 
      the corresponding polyester-based scaffold. Rabbits were euthanized 4, 12 and 20 
      weeks after surgery and the condyles dissected and processed for histology. 
      RESULTS: Only ACP-treated defects presented bone at the base of the defect at 4 
      weeks. At 12 weeks, only defects treated with rapidly dissolving implants (ACP 
      and PLGA) presented bone reconstitution consistently, while bone was present in 
      only one third of those treated with slowly dissolving scaffolds (HYAFF-11 and 
      PLLA). After 20 weeks, the articular surface of PLGA-treated defects presented 
      fibrillation more frequently than in ACP-treated defects. The surface of defects 
      treated with slowly dissolving scaffolds presented more cracks and fissures. 
      CONCLUSIONS: The degradation rate of the scaffolds is critical for the repair 
      process. Slowly dissolving scaffolds sustain thicker cartilage at the surface 
      but, it frequently presents cracks and discontinuities. These scaffolds also 
      delay bone formation at the base of the defects. Hyaluronan-based scaffolds 
      appear to allow faster cell infiltration leading to faster tissue formation. The 
      degradation of ACP leads to rapid bone formation while the slow degradation of 
      HYAFF-11 prolongs the presence of cartilage and delays endochondral bone 
      formation.
FAU - Solchaga, Luis A
AU  - Solchaga LA
AD  - Department of Orthopaedics, Case Western Reserve University School of Medicine 
      and University Hospitals of Cleveland, Cleveland, OH, USA. las29@po.cwru.edu
FAU - Temenoff, Johnna S
AU  - Temenoff JS
FAU - Gao, Jizong
AU  - Gao J
FAU - Mikos, Antonios G
AU  - Mikos AG
FAU - Caplan, Arnold I
AU  - Caplan AI
FAU - Goldberg, Victor M
AU  - Goldberg VM
LA  - eng
GR  - R01-AR37726/AR/NIAMS NIH HHS/United States
GR  - R01-AR48756/AR/NIAMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Substitutes)
RN  - 0 (Polyesters)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials
MH  - Bone Substitutes/*therapeutic use
MH  - Cartilage, Articular/*injuries/pathology
MH  - Chemical Phenomena
MH  - Chemistry, Physical
MH  - Chondrogenesis
MH  - Hyaluronic Acid/*therapeutic use/ultrastructure
MH  - Materials Testing/methods
MH  - Microscopy, Electron, Scanning
MH  - Polyesters/chemistry/therapeutic use
MH  - Rabbits
MH  - Tissue Engineering/*methods
MH  - Wound Healing/physiology
EDAT- 2005/03/23 09:00
MHDA- 2005/07/06 09:00
CRDT- 2005/03/23 09:00
PHST- 2004/10/03 00:00 [received]
PHST- 2004/12/20 00:00 [accepted]
PHST- 2005/03/23 09:00 [pubmed]
PHST- 2005/07/06 09:00 [medline]
PHST- 2005/03/23 09:00 [entrez]
AID - S1063-4584(04)00291-2 [pii]
AID - 10.1016/j.joca.2004.12.016 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2005 Apr;13(4):297-309. doi: 
      10.1016/j.joca.2004.12.016.