PMID- 15781051
OWN - NLM
STAT- MEDLINE
DCOM- 20050830
LR  - 20190508
IS  - 0006-8993 (Print)
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1039
IP  - 1-2
DP  - 2005 Mar 28
TI  - 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats 
      increases pituitary-adrenal output and reduces striatal and hippocampal serotonin 
      without altering SERT activity.
PG  - 97-107
AB  - We have previously shown that +/-3,4-methylenedioxymethamphetamine (MDMA) 
      treatment from P11 to P20 in rats produces deficits in cognitive ability when 
      these animals are tested in adulthood. The purpose of this experiment was to 
      explore the neuroendocrine and neurochemical changes produced by MDMA treatment 
      on P11. We examined monoamines in the hippocampus and striatum and the serotonin 
      transporter in the hippocampus as well as pituitary and adrenal output following 
      administration of MDMA (10 mg/kg, 4 times) on postnatal day 11. Significant 
      depletions in serotonin were evident in the hippocampus 1 h and in the striatum 
      24 h after the first dose and remained reduced 78 h later. No changes in 
      serotonin transporter were observed following MDMA treatment, although females 
      had lower levels than males. No changes in dopamine were detected. The 
      metabolites of serotonin and dopamine had different profiles than the parent 
      compounds after MDMA administration. Plasmatic ACTH was elevated immediately 
      following MDMA and remained elevated for at least 1 h after the last dose and 
      returned to baseline by 24 h. Corticosterone was increased after the first dose 
      and remained increased for at least 24 h, and returned to baseline by 30 h. The 
      decreases in serotonin in regions important for learning and memory in 
      conjunction with elevated levels of corticosterone during a period of stress 
      hyporesponsiveness suggest that these initial responses to MDMA may contribute to 
      the long-term learning and memory deficits following neonatal MDMA exposure.
FAU - Williams, Michael T
AU  - Williams MT
AD  - Division of Child Neurology, Cincinnati Children's Hospital Research Foundation 
      and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, 
      OH 45229-3039, USA. michael.williams@cchmc.org
FAU - Schaefer, Tori L
AU  - Schaefer TL
FAU - Ehrman, Lisa A
AU  - Ehrman LA
FAU - Able, Jessica A
AU  - Able JA
FAU - Gudelsky, Gary A
AU  - Gudelsky GA
FAU - Sah, Renu
AU  - Sah R
FAU - Vorhees, Charles V
AU  - Vorhees CV
LA  - eng
GR  - K01 DA014269-05/DA/NIDA NIH HHS/United States
GR  - R01 DA021394-01/DA/NIDA NIH HHS/United States
GR  - DA14269/DA/NIDA NIH HHS/United States
GR  - DA11902/DA/NIDA NIH HHS/United States
GR  - K01 DA014269/DA/NIDA NIH HHS/United States
GR  - R01 DA021394/DA/NIDA NIH HHS/United States
GR  - T32 ES007051/ES/NIEHS NIH HHS/United States
GR  - R01 DA007427-13/DA/NIDA NIH HHS/United States
GR  - ES07051/ES/NIEHS NIH HHS/United States
GR  - R01 DA011902-03/DA/NIDA NIH HHS/United States
GR  - DA07427/DA/NIDA NIH HHS/United States
GR  - R01 DA007427/DA/NIDA NIH HHS/United States
GR  - T32 ES007051-34/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Serotonin Agents)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Slc6a4 protein, rat)
RN  - 333DO1RDJY (Serotonin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood/drug effects
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Corpus Striatum/*drug effects/metabolism
MH  - Corticosterone/blood
MH  - Dopamine/metabolism
MH  - Female
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Membrane Glycoproteins/drug effects/*metabolism
MH  - Membrane Transport Proteins/drug effects/*metabolism
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Nerve Tissue Proteins/drug effects/*metabolism
MH  - Organ Size/drug effects
MH  - Pituitary-Adrenal System/*drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/drug effects
MH  - Serotonin/metabolism
MH  - Serotonin Agents/*toxicity
MH  - Serotonin Plasma Membrane Transport Proteins
MH  - Sex Factors
MH  - Thymus Gland/pathology
PMC - PMC2888318
MID - NIHMS207851
EDAT- 2005/03/23 09:00
MHDA- 2005/09/01 09:00
PMCR- 2010/06/21
CRDT- 2005/03/23 09:00
PHST- 2004/07/29 00:00 [received]
PHST- 2005/01/13 00:00 [revised]
PHST- 2005/01/13 00:00 [accepted]
PHST- 2005/03/23 09:00 [pubmed]
PHST- 2005/09/01 09:00 [medline]
PHST- 2005/03/23 09:00 [entrez]
PHST- 2010/06/21 00:00 [pmc-release]
AID - S0006-8993(05)00116-2 [pii]
AID - 10.1016/j.brainres.2005.01.045 [doi]
PST - ppublish
SO  - Brain Res. 2005 Mar 28;1039(1-2):97-107. doi: 10.1016/j.brainres.2005.01.045.