PMID- 15784184
OWN - NLM
STAT- MEDLINE
DCOM- 20050719
LR  - 20220408
IS  - 1286-4579 (Print)
IS  - 1769-714X (Electronic)
IS  - 1286-4579 (Linking)
VI  - 7
IP  - 3
DP  - 2005 Mar
TI  - Th2 predominance and CD8+ memory T cell depletion in patients with severe acute 
      respiratory syndrome.
PG  - 427-36
AB  - The immune spectrum of severe acute respiratory syndrome (SARS) is poorly 
      understood. To define the dynamics of the immune spectrum in SARS, serum levels 
      of cytokines, chemokines, immunoglobulins, complement and specific antibodies 
      against SARS-associated coronavirus (SARS-CoV) were assayed by enzyme-linked 
      immunosorbent assay (ELISA), and phenotypes of peripheral lymphocytes were 
      analyzed by flow cytometry in 95 SARS-infected patients. Results showed that 
      interleukin (IL)-10 and transforming growth factor beta (TGF-beta) were 
      continuously up-regulated during the entirety of SARS. Regulated on activation 
      normally T cell-expressed and secreted (RANTES) levels were decreased, while 
      monocyte chemoattractant protein-1 (MCP-1) was elevated in acute patients. 
      Immunoglobulins and complement were elevated during the first month of SARS. Both 
      serum-positive rates and titers of specific IgM and IgG antibodies responding to 
      SARS-CoV peaked at days 41-60 from the onset of SARS. CD4+ and CD8+ T lymphocytes 
      decreased significantly in acute-phase. CD3+CD8+CD45RO+ T lymphocytes were 
      decreased by 36.78% in the convalescent patients. CONCLUSION: SARS-CoV seemed to 
      elicit effective humoral immunity but inhibited cellular immunity, especially 
      CD8+ memory T lymphocytes over time. Prolonged overproduction of IL-10 and 
      TGF-beta may play an important role in the disease.
FAU - Huang, Jia-Ling
AU  - Huang JL
AD  - Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative 
      Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng 
      Road East, Guangzhou 510060, China.
FAU - Huang, Jian
AU  - Huang J
FAU - Duan, Zhao-Hui
AU  - Duan ZH
FAU - Wei, Jing
AU  - Wei J
FAU - Min, Jun
AU  - Min J
FAU - Luo, Xiao-Hong
AU  - Luo XH
FAU - Li, Jian-Guo
AU  - Li JG
FAU - Tan, Wei-Ping
AU  - Tan WP
FAU - Wu, Li-Zhi
AU  - Wu LZ
FAU - Liu, Ran-Yi
AU  - Liu RY
FAU - Li, Yan
AU  - Li Y
FAU - Shao, Jing
AU  - Shao J
FAU - Huang, Bi-Jun
AU  - Huang BJ
FAU - Zeng, Yi-Xin
AU  - Zeng YX
FAU - Huang, Wenlin
AU  - Huang W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050224
PL  - France
TA  - Microbes Infect
JT  - Microbes and infection
JID - 100883508
RN  - 0 (Transforming Growth Factor beta)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Female
MH  - Humans
MH  - Interleukin-10/immunology/physiology
MH  - Male
MH  - Severe Acute Respiratory Syndrome/*immunology
MH  - Th2 Cells/*immunology
MH  - Time Factors
MH  - Transforming Growth Factor beta/immunology/physiology
PMC - PMC7110803
EDAT- 2005/03/24 09:00
MHDA- 2005/07/20 09:00
PMCR- 2005/02/24
CRDT- 2005/03/24 09:00
PHST- 2004/10/19 00:00 [received]
PHST- 2004/11/24 00:00 [revised]
PHST- 2004/11/25 00:00 [accepted]
PHST- 2005/03/24 09:00 [pubmed]
PHST- 2005/07/20 09:00 [medline]
PHST- 2005/03/24 09:00 [entrez]
PHST- 2005/02/24 00:00 [pmc-release]
AID - S1286-4579(05)00030-4 [pii]
AID - 10.1016/j.micinf.2004.11.017 [doi]
PST - ppublish
SO  - Microbes Infect. 2005 Mar;7(3):427-36. doi: 10.1016/j.micinf.2004.11.017. Epub 
      2005 Feb 24.