PMID- 15784408
OWN - NLM
STAT- MEDLINE
DCOM- 20050711
LR  - 20131121
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 30
IP  - 1
DP  - 2005 Apr 7
TI  - Circulating tumor necrosis factor alpha is higher in non-obese, non-diabetic 
      Mexican Americans compared to non-Hispanic white adults.
PG  - 14-21
AB  - Mexican Americans (MA) exhibit high risk for the insulin resistance syndrome 
      characterized by subclinical inflammation and greater risk for type 2 diabetes 
      compared with non-Hispanic white (NHW) adults. The reasons for this phenomenon 
      remain obscure. Because the inflammatory cytokine, tumor necrosis factor-alpha 
      (TNF alpha), is associated with insulin resistance in various models of obesity 
      and diabetes, we sought to determine whether circulating concentrations of this 
      cytokine and its soluble receptors are higher in MA than NHW, and also to 
      determine if the TNF alpha system is related to the lower insulin sensitivity in 
      MA. Fasting blood samples were used to determine concentrations of TNF alpha, 
      soluble TNF receptors 1 (sTNFR1) and 2 (sTNFR2) in the same 13 MA (7 women, 6 
      men, age=27.0+/-2.0 years, BMI=23.0+/-0.7) and 13 NHW (7 women, 6 men, 
      age=24.8+/-1.5 years, BMI=22.8+/-0.6) previously shown to exhibit differences in 
      insulin sensitivity. Circulating TNF alpha was significantly higher (3.11+/-0.38 
      vs. 2.10+/-0.24 pg/ml, p<0.05) and sTNFR2 was significantly lower (1324+/-85 vs. 
      1925+/-127 pg/ml, p<0.05) among MA compared with NHW subjects. Soluble TNFR1 was 
      not different between groups (MA: 970+/-111 pg/ml vs. NHW: 1218+/-73 pg/ml, 
      p=0.07). TNF alpha, sTNFR1 and sTNFR2 were not correlated with HOMA-IR when the 
      two groups were analyzed in aggregate. This study documents higher circulating 
      TNF alpha concentrations in non-obese, non-diabetic MA, a population group at 
      increased risk for the metabolic syndrome and the untoward effects of 
      sub-clinical inflammation. The clinical implications of this difference, if any, 
      are not yet known.
FAU - Ho, Richard C
AU  - Ho RC
AD  - Colorado State University, Department of Food Science and Human Nutrition, 
      Nutrition and Metabolic Fitness Laboratory, 234 Gifford, Fort Collins, CO 80523, 
      USA.
FAU - Davy, Kevin P
AU  - Davy KP
FAU - Hickey, Matthew S
AU  - Hickey MS
FAU - Melby, Christopher L
AU  - Melby CL
LA  - eng
GR  - F31 DK10057-02/DK/NIDDK NIH HHS/United States
GR  - HL62283/HL/NHLBI NIH HHS/United States
GR  - HL67227/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Insulin)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Body Height
MH  - Body Mass Index
MH  - Body Weight
MH  - Female
MH  - Glucose/metabolism
MH  - Humans
MH  - Inflammation
MH  - Insulin/metabolism
MH  - Insulin Resistance/*ethnology
MH  - Male
MH  - Mexican Americans
MH  - Mexico
MH  - Obesity/blood
MH  - Receptors, Tumor Necrosis Factor, Type I/blood
MH  - Receptors, Tumor Necrosis Factor, Type II/blood
MH  - Risk
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
MH  - United States
EDAT- 2005/03/24 09:00
MHDA- 2005/07/12 09:00
CRDT- 2005/03/24 09:00
PHST- 2004/08/13 00:00 [received]
PHST- 2004/10/15 00:00 [revised]
PHST- 2004/10/19 00:00 [accepted]
PHST- 2005/03/24 09:00 [pubmed]
PHST- 2005/07/12 09:00 [medline]
PHST- 2005/03/24 09:00 [entrez]
AID - S1043-4666(05)00016-5 [pii]
AID - 10.1016/j.cyto.2004.10.015 [doi]
PST - ppublish
SO  - Cytokine. 2005 Apr 7;30(1):14-21. doi: 10.1016/j.cyto.2004.10.015.