PMID- 15784467
OWN - NLM
STAT- MEDLINE
DCOM- 20050815
LR  - 20061115
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 3
DP  - 2005 Mar
TI  - Single nucleotide polymorphisms in the regulatory regions of the 
      HLA-DRB-expressed genes.
PG  - 290-4
AB  - DRB genes encode proteins that play an important role in the immune response, and 
      their expressional regulation is crucial to the immune reaction. Sequence 
      variation at the regulatory region can directly affect the gene expression level. 
      The aim of the present study was to use Chinese samples to investigate the 
      variation in the regulation region of the human leukocyte antigen 
      (HLA)-DRB-expressed genes. Seventy- one single nucleotide polymorphisms (SNPs) 
      were found in the four HLA-DRB-expressed genes. By comparing these data with SNPs 
      in the U.S. National Center for Biotechnology Information dbSNP database, 69 SNPs 
      (97.2%) were found to be novel. In addition, two genetic variations of 
      insertion-deletion polymorphisms were discovered within the regulatory region of 
      HLA-DRB1 gene. These polymorphisms can be used as resources of markers for 
      association studies of complex diseases, for assessment of individual 
      predisposition to diseases, and as research markers for population genetics and 
      evolution.
FAU - Fan, Xinlan
AU  - Fan X
AD  - Key Laboratory of Genetic Engineering of MOE, Department of Biochemistry, College 
      of Life Sciences, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510275, PR 
      China.
FAU - Lan, Dongming
AU  - Lan D
FAU - Lin, Bin
AU  - Lin B
FAU - Xie, Yi
AU  - Xie Y
FAU - Liu, Zehuan
AU  - Liu Z
FAU - Zhen, Guoqing
AU  - Zhen G
FAU - Fu, Yonggui
AU  - Fu Y
FAU - Xu, Anlong
AU  - Xu A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Base Sequence
MH  - *Genes, Regulator
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - *Polymorphism, Single Nucleotide
MH  - Sequence Alignment
EDAT- 2005/03/24 09:00
MHDA- 2005/08/16 09:00
CRDT- 2005/03/24 09:00
PHST- 2004/04/20 00:00 [received]
PHST- 2004/10/24 00:00 [revised]
PHST- 2004/11/03 00:00 [accepted]
PHST- 2005/03/24 09:00 [pubmed]
PHST- 2005/08/16 09:00 [medline]
PHST- 2005/03/24 09:00 [entrez]
AID - S0198-8859(04)00681-0 [pii]
AID - 10.1016/j.humimm.2004.11.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Mar;66(3):290-4. doi: 10.1016/j.humimm.2004.11.003.