PMID- 15784469
OWN - NLM
STAT- MEDLINE
DCOM- 20050815
LR  - 20181113
IS  - 0198-8859 (Print)
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 3
DP  - 2005 Mar
TI  - Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) 
      susceptibility and age at T1D onset.
PG  - 301-13
AB  - Alleles of human leukocyte antigen (HLA) class II genes are well known to affect 
      susceptibility to type 1 diabetes (T1D), but less is known about the contribution 
      of HLA class I alleles to T1D susceptibility. In this study, molecular genotyping 
      was performed at the HLA-B and HLA-C loci for 283 multiplex Caucasian families, 
      previously typed for HLA-A and the class II loci. Allele frequencies were 
      compared between affected siblings and affected family-based controls. Linkage 
      disequilibrium coefficients were calculated for HLA-B-HLA-C haplotypes and for 
      class I-lass II haplotypes. After adjustment for linkage disequilibrium, the 
      following alleles remain associated with T1D: B*1801, B*3906, B*4403, C*0303, 
      C*0802, and C*1601. B and C allele associations were tested for certain 
      T1D-associated DRB1-DQB1 haplotypes, with the following results: B*3801 is 
      protective on DRB1*0401-DQB1*0302 haplotypes, both C*0701 and C*0702 are 
      predisposing on DRB1*0404-DQB1*0302 haplotypes, and B*3906 is predisposing on 
      DRB1*0801-DQB1*0402 haplotypes. As with previous results for HLA-A, HLA-B and 
      HLA-C are associated with age at T1D onset (mean 11.6 +/- 0.3 years). The 
      protective allele B*4403 was associated with older age at onset (15.1 years; p < 
      0.04), and the predisposing alleles C*0702 and B*3906 were associated with 
      younger age at onset (9.5 years, p < 0.001; and 7.8 years, p < 0.002, 
      respectively). These data support a role for HLA class I alleles in 
      susceptibility to and age at onset of T1D.
FAU - Valdes, Ana M
AU  - Valdes AM
AD  - Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
FAU - Erlich, Henry A
AU  - Erlich HA
FAU - Noble, Janelle A
AU  - Noble JA
LA  - eng
GR  - R01 DK061722/DK/NIDDK NIH HHS/United States
GR  - R56 DK061722/DK/NIDDK NIH HHS/United States
GR  - DK46626/DK/NIDDK NIH HHS/United States
GR  - DK61722/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Age of Onset
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics/immunology
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Histocompatibility Antigens Class II/genetics/immunology
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Odds Ratio
PMC - PMC4049521
MID - NIHMS572780
EDAT- 2005/03/24 09:00
MHDA- 2005/08/16 09:00
PMCR- 2014/06/09
CRDT- 2005/03/24 09:00
PHST- 2004/09/29 00:00 [received]
PHST- 2004/11/29 00:00 [revised]
PHST- 2004/12/01 00:00 [accepted]
PHST- 2005/03/24 09:00 [pubmed]
PHST- 2005/08/16 09:00 [medline]
PHST- 2005/03/24 09:00 [entrez]
PHST- 2014/06/09 00:00 [pmc-release]
AID - S0198-8859(04)00689-5 [pii]
AID - 10.1016/j.humimm.2004.12.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Mar;66(3):301-13. doi: 10.1016/j.humimm.2004.12.001.